Publications by authors named "Jeremy Johns"
Background: Despite consensus guidelines, concern about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission has dissuaded patients with cancer from seeking medical care. Studies have shown that contaminated surfaces may contain viable virus for up to 72 hours in laboratory settings. The purpose of this study was to investigate contamination of SARS-CoV-2 on commonly used environmental surfaces in a tertiary cancer care center.
View Article and Find Full Text PDFOncogenesis is driven by germline, environmental and stochastic factors. It is unknown how these interact to produce the molecular phenotypes of tumors. We therefore quantified the influence of germline polymorphisms on the somatic epigenome of 589 localized prostate tumors.
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- Prostate tumours show diverse responses to treatment, and current prognostic factors only account for some of this variation, prompting further investigation into their genetic profiles.* -
- Analysis of 200 whole-genome and 277 whole-exome sequences revealed that localized, non-indolent tumours lack key mutations found in metastatic cases, instead featuring non-coding changes and large-scale rearrangements.* -
- Many genetic abnormalities were linked to disease recurrence, and a new signature of these abnormalities was found to be more effective than established biomarkers, suggesting that targeted treatments could enhance cure rates for aggressive localized prostate cancer.*
Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor lesions, termed pancreatic intraepithelial neoplasm (PanINs) lesions, makes two predictions: first, that pancreatic cancer develops through a particular sequence of genetic alterations (KRAS, followed by CDKN2A, then TP53 and SMAD4); and second, that the evolutionary trajectory of pancreatic cancer progression is gradual because each alteration is acquired independently. A shortcoming of this model is that clonally expanded precursor lesions do not always belong to the tumour lineage, indicating that the evolutionary trajectory of the tumour lineage and precursor lesions can be divergent.
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- Researchers studied 74 patients with a type of prostate cancer called Gleason score 7 to understand how different parts of their tumors were unique.
- They looked closely at 5 patients by analyzing 23 specific areas of their tumors and found lots of differences in the cancer's genetic makeup.
- A new gene called MYCL was found to be important, and this study helps doctors predict how a patient's cancer might behave, which could lead to better treatments in the future.
Composites of extracellular matrix proteins reinforced with carbon nanotubes have the potential to be used as conductive biopolymers in a variety of biomaterial applications. In this study, the effect of functionalization and polymer wrapping on the dispersion of multiwalled carbon nanotubes (MWCNT) in aqueous media was examined. Carboxylated MWCNT were wrapped in either Pluronic(®) F127 or gelatin.
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