A randomized, controlled crossover trial of ondansetron in patients with primary biliary cirrhosis and fatigue.

Fatigue is common in primary biliary cirrhosis (PBC). Altered central serotonergic neurotransmission may be involved in its pathogenesis. This multicenter, randomized, double-blind, placebo-controlled, crossover trial evaluated the efficacy of ondansetron, a selective 5-HT3 receptor subtype antagonist, for treating fatigue in PBC.

Digital video for the documentation of colonoscopy.

Background: The aim of this study was to determine whether digital video is suitable for the documentation of colonoscopy. Standards are required for the visual documentation of endoscopic findings and to optimize image quality while limiting file size and bandwidth requirements.

Methods: Video recordings of colonoscopy procedures were encoded using a common video compression method at selected data rates and resolutions.