Publications by authors named "Jeremy E O'Neal"
Mol Pharmacol
February 2017
Article Synopsis
- CRIP1a interacts with cannabinoid receptors (CBRs) and influences how these receptors interact with G-proteins and β-arrestin proteins.
- Coimmunoprecipitation studies show that CRIP1a and β-arrestin cannot bind simultaneously to the CBR, indicating they compete for the same binding sites.
- Overexpressing CRIP1a reduces the redistribution of β-arrestin during receptor internalization, while knocking it down increases β-arrestin activity, suggesting that CRIP1a plays a key role in regulating CBR internalization through its interaction with β-arrestin.
