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Publications by authors named "Jeremy A Ryan"

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Synopsis of recent research by authors named "Jeremy A Ryan"

  • Jeremy A. Ryan's research primarily focuses on understanding the mechanisms of acquired drug resistance in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) through innovative methodologies such as patient-derived xenografts and CRISPR screening.
  • Recent findings emphasize that low apoptotic priming and specific pathway activations (e.g., RAS/MAPK) play crucial roles in mediating resistance to targeted therapies like venetoclax and other BH3 mimetics in AML.
  • Ryan's work also highlights the development of new therapeutic strategies targeting vulnerabilities identified through genetic screening and profiling, aiming to improve treatment outcomes for patients with these malignancies.

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