Publications by authors named "Jeremie Ngezahayo"

Article Synopsis
  • Guava fruits, commonly used in Malagasy traditional medicine, were tested for their antibacterial properties against the bacteria PAO1, focusing on their ability to combat gastrointestinal infections.
  • While three organic extracts showed no direct antibacterial effects, the hexane and dichloromethane extracts demonstrated significant anti-biofilm properties and disrupted bacterial movement.
  • Lycopene and β-sitosterol-β-D-glucoside were identified as major anti-biofilm compounds in the dichloromethane extract, enhancing the effectiveness of tobramycin against biofilm-encapsulated PAO1.
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Ethnopharmacological Relevance: The main objective of the present study was to collect and gather information on herbal remedies traditionally used for the treatment of malaria in Bukavu and Uvira, two towns of the South Kivu province in DRC.

Material And Methods: Direct interview with field enquiries allowed collecting ethnobotanical data; for each plant, a specimen was harvested in the presence of the interviewed traditional healers (THs). The recorded information included vernacular names, morphological parts of plants, methods of preparation and administration of remedies, dosage and treatment duration.

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The emergence of antimicrobial resistant infectious diseases remains a major threat to worldwide public health, in developed and in developing countries. Therefore, new antimicrobial agents acting by new mechanisms of action are urgently needed. As plants used in traditional medicine may help to overcome these problems, Justicia subsessilis, Platostoma rotundifolium, Pavetta ternifolia, Stomatanthes africanus, and Virectaria major (plants highly cited to be used against microbial infections in traditional Burundian medicine) were studied to assess their traditional use efficacy.

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Ethnopharmacological Relevance: Infectious diseases represent a serious and worldwide public health problem. They lead to high mortality, especially in non-developed countries. In Burundi, the most frequent infectious diseases are skin and respiratory (mainly in children) infections, diarrhea, added to malaria, HIV/AIDS and tuberculosis.

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