Publications by authors named "Jeremie Ghiotto"
Article Synopsis
- Ex vivo testing is crucial for identifying promising anticoagulant agents, with this study focusing on validating the thrombin generation assay for evaluating their effectiveness.
- Six anticoagulant drugs were tested using the Calibrated Automated Thrombogram (CAT) method to observe their effects on thrombin activity in healthy male volunteers, showing varying potency and mechanisms of action among the drugs.
- The CAT method proved to be a fast, reliable tool for screening these anticoagulants, offering advantages over traditional tests like the PT clotting assay by providing detailed insights into thrombin generation dynamics.
The prostanoid thromboxane (TX)A2 exerts its proaggregant and constrictive actions upon binding to the specific TXA2 receptor (TP), a member of the G-protein coupled receptor superfamily. In humans, TXA2 signals through two distinct TP isoforms, TPalpha and TPbeta. Herein, we describe the design, synthesis, and SAR study of a series of original N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine.
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