Publications by authors named "Jeremiah Shultz"
Article Synopsis
- Guidelines suggest follow-up endoscopic surveillance for nonpedunculated colorectal lesions ≥20 mm after piecemeal EMR should be 6 months, but this study questions if a 12-month interval is sufficient for low-risk cases.
- The analysis involved 561 colorectal lesions and found similar recurrence rates (10%) for both the 6-month and 12-month surveillance groups, although the lesions in the 12-month group were typically smaller and less aggressive.
- The findings support the potential for 12-month surveillance as a reasonable option for certain patients, which could reduce healthcare costs and patient burden while maintaining safety.
Article Synopsis
- Prophylactic closure using clips after endoscopic resections helps decrease the risk of delayed hemorrhage, particularly for larger non-pedunculated colorectal lesions removed using electrocautery.
- Cold resections, which are less invasive and have a lower risk of bleeding, generally do not require clip closure, and audit of clip usage revealed varying and often unnecessary application for smaller lesions.
- A study involving 3,784 colorectal lesions showed that clip placement was significantly more common after electrocautery (71.1%) compared to cold resection (3.9%), indicating potential areas for improving practice and reducing waste in outpatient colonoscopy procedures.
Background & Aims: Thermal treatment of the defect margin after endoscopic mucosal resection (EMR) of large nonpedunculated colorectal lesions reduces the recurrence rate. Both snare tip soft coagulation (STSC) and argon plasma coagulation (APC) have been used for thermal margin treatment, but there are few data directly comparing STSC with APC for this indication.
Methods: We performed a randomized 3-arm trial in 9 US centers comparing STSC with APC with no margin treatment (control) of defects after EMR of colorectal nonpedunculated lesions ≥15 mm.
Osteosarcoma (OS) patients exhibit poor overall survival, partly due to copy number variations (CNVs) resulting in dysregulated gene expression and therapeutic resistance. To identify actionable prognostic signatures of poor overall survival, we employed a systems biology approach using public databases to integrate CNVs, gene expression, and survival outcomes in pediatric, adolescent, and young adult OS patients. Chromosome 8 was a hotspot for poor prognostic signatures.
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