Effect of hydroxychloroquine or chloroquine and short wavelength light on retinal function and structure in mouse eyes.

Clinical Relevance: The use of chloroquine or hydroxychloroquine can lead to both acute and chronic changes to both retinal structure and function.

Background: Chloroquine (CQ) and hydroxychloroquine (HCQ) have the potential for retina toxicity. The acute impact of short-term drug exposure (2-4 weeks) on in vivo retinal structure and function and assess whether short wavelength light exposure further exacerbates any structural and functional changes was assessed in a murine model.

Retinal changes in Alzheimer's disease- integrated prospects of imaging, functional and molecular advances.

Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically characterised by cognitive deficits that gradually worsen over time. There is, at present, no established cure, or disease-modifying treatments for AD. As life expectancy increases globally, the number of individuals suffering from the disease is projected to increase substantially.