Publications by authors named "Jeremey Stone"
Article Synopsis
- A study conducted at a public university in Seattle evaluated the effectiveness of SARS-CoV-2 antigen-detection rapid diagnostic tests (Ag-RDTs) in comparison to traditional rRT-PCR testing over a period from February to December 2022.
- Out of 5,757 participants, those who took 12,674 rRT-PCR tests found 7.9% positive, with Ag-RDTs showing an overall sensitivity of 53% and specificity of 98.8%.
- The study concluded that Ag-RDT sensitivity improved with sequential testing, particularly after initial negative results, and recommended repeat testing for symptomatic individuals or those at high risk.
Vaccine effectiveness (VE) studies utilizing the test-negative design are typically conducted in clinical settings, rather than community populations, leading to bias in VE estimates against mild disease and limited information on VE in healthy young adults. In a community-based university population, we utilized data from a large SARS-CoV-2 testing program to estimate relative VE of COVID-19 mRNA vaccine primary series and monovalent booster dose versus primary series only against symptomatic SARS-CoV-2 infection from September 2021 to July 2022. We used the test-negative design and logistic regression implemented via generalized estimating equations adjusted for age, calendar time, prior SARS-CoV-2 infection, and testing frequency (proxy for test-seeking behavior) to estimate relative VE.
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