Publications by authors named "Jerdravee Morrison"
Background: Interactions between human immuno-deficiency virus (HIV) and opioid-dependence therapies can occur.
Objectives: We sought to determine whether such interactions occurred between buprenorphine/naloxone and raltegravir.
Methods: We performed a within-subject open-labeled pharmacokinetic and pharmacodynamic study in 12 HIV-seronegative subjects stabilized on at least 3 weeks of buprenorphine/naloxone therapy.
Gender differences in pharmacokinetics of maintenance dosed buprenorphine.
Drug Alcohol Depend
November 2011
Article Synopsis
- This study investigates how gender affects the pharmacokinetics of buprenorphine, focusing on differences in drug metabolism and body composition.
- A retrospective analysis was conducted on control sessions of buprenorphine/naloxone in both males and females, revealing that females generally have higher plasma concentrations of buprenorphine and its metabolites.
- The findings suggest that body composition differences significantly influence pharmacokinetics, and there may also be a role for gender-based variations in CYP3A metabolism.