Contemporary multimodal approach to diagnosis and treatment of vascular graft and endograft infections.

Vascular graft and endograft infections (VGEIs) are a feared complication because of their morbidity, cost, and mortality. Despite broad and varying strategies, as well as limited evidence, societal guidelines do exist. The objective of this review was to supplement current guidelines with emerging and multimodal techniques for treatment.

Efficacy and Safety of Exercise Testing and Rehabilitation for Aortic Dissection Patients: A SCOPING REVIEW.

Objective: Although physical exercise has established benefits for long-term cardiovascular health, concern regarding further aortic events has limited the evidence for exercise among aortic dissection (AD) patients. The objective was to perform a scoping review of the current concepts and gaps in the literature regarding the benefit and safety of cardiovascular testing and rehabilitation among post-AD patients.

Review Methods: A scoping review of the literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR).

Effects of chemotherapy dose reductions in overweight patients with acute myeloid leukaemia: A Danish nationwide cohort study.

Overweight patients with cancer are frequently reduced in chemotherapy dose due to toxicity concerns, although previous studies have indicated that dose reduction (DR) of overweight patients results in comparable toxicity but may compromise overall survival (OS). Current evidence regarding DR in patients with acute myeloid leukaemia (AML) is limited. To investigate the association between DR and outcome among overweight patients with AML we analysed a Danish nationwide cohort of overweight adult AML patients treated with remission induction chemotherapy.

A national Danish proof of concept on feasibility and safety of home -based intensive chemotherapy in patients with acute myeloid leukemia.

Technological advances have made it possible to offer home-based chemotherapy to patients without health care professionals being present. Prior studies on effects of home-based treatment lack inclusion of patients with hematologic malignancies. We present data from a multicenter single-arm feasibility and safety study of home-based intensive chemotherapy in patients with newly diagnosed acute myeloid leukemia and their quality of life and psychological wellbeing.

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding.

Kinesins are regulated in space and time to ensure activation only in the presence of cargo. Kinesin-binding protein (KIFBP), which is mutated in Goldberg-Shprintzen syndrome, binds to and inhibits the catalytic motor heads of 8 of 45 kinesin superfamily members, but the mechanism remains poorly defined. Here, we used cryo–electron microscopy and cross-linking mass spectrometry to determine high-resolution structures of KIFBP alone and in complex with two mitotic kinesins, revealing structural remodeling of kinesin by KIFBP.

Social media use and postpartum body image dissatisfaction: The role of appearance-related social comparisons and thin-ideal internalization.

Objectives: For many women, the postpartum period is a particularly vulnerable time to experience body image dissatisfaction. We aimed to examine the impact of social media usage frequency in the context of postpartum body image dissatisfaction and eating disorder psychopathology. We therefore empirically tested a hypothetical model assuming that social media usage influences postpartum body image dissatisfaction and eating disorder psychopathology via multiple mediation through appearance-related social comparisons and thin ideal internalization.

Effects of Nucleotide and End-Dependent Actin Conformations on Polymerization.

The regulation of actin is key for controlled cellular function. Filaments are regulated by actin-binding proteins, but the nucleotide state of actin is also an important factor. From extended molecular dynamics simulations, we find that both nucleotide states of the actin monomer have significantly less twist than their crystal structures and that the ATP monomer is flatter than the ADP form.

Structural Diversity and Trends in Properties of an Array of Hydrogen-Rich Ammonium Metal Borohydrides.

Metal borohydrides are a fascinating and continuously expanding class of materials, showing promising applications within many different fields of research. This study presents 17 derivatives of the hydrogen-rich ammonium borohydride, NHBH, which all exhibit high gravimetric hydrogen densities (>9.2 wt % of H).

Ammine Lanthanum and Cerium Borohydrides, (BH)·NH; Trends in Synthesis, Structures, and Thermal Properties.

Ammine metal borohydrides show potential for solid-state hydrogen storage and can be tailored toward hydrogen release at low temperatures. Here, we report the synthesis and structural characterization of seven new ammine metal borohydrides, (BH)·NH, M = La ( = 6, 4, or 3) or Ce ( = 6, 5, 4, or 3). The two compounds with = 6 are isostructural and have new orthorhombic structure types (space group 222) built from cationic complexes, [(NH)(BH)], and are charge balanced by BH.

Utilization of e-mental-health and online self-management interventions of patients with mental disorders-A cross-sectional analysis.

Background: Web-based treatments and online self-management interventions extend the range of therapeutic supply. Since the number of online self-management interventions is steadily increasing, we aimed to examine, how web-based services currently influence mental health care, asking about previous internet use and future interests of patients with mental disorders.

Methods: We consulted patients (n = 400) from all services of the Department of Psychiatry and Psychotherapy of the University of Leipzig using a 28-item questionnaire.

Rehabilitation during intensive treatment of acute leukaemia including allogenic stem cell transplantation: a qualitative study of patient experiences.

Objectives: The diagnosis and treatment of acute leukaemia (AL) affect physical, psychosocial and existential functioning. Long-lasting treatment periods with impaired immune system, hygienic and social restrictions challenge patient well-being and rehabilitation as compared with other individuals with cancer. This study elucidates how AL patients, treated with curative intent in an outpatient setting, assess their physical, psychosocial and existential capability during and following treatment, and furthermore reports on the health initiatives offered to support their rehabilitation.

5-year outcome after complete mesocolic excision for right-sided colon cancer: a population-based cohort study.

Background: The benefits of extensive lymph node dissection as performed in complete mesocolic excision are still debated, although recent studies have shown an association with improved long-term outcomes. However, none of these studies had an intention-to-treat design or aimed to show a causal effect; therefore in this study, we aimed to estimate the causal oncological treatment effects of complete mesocolic excision on right-sided colon cancer.

Methods: We did a population-based cohort study involving prospective data collected from four hospitals in Denmark.

Measuring body image during pregnancy: psychometric properties and validity of a German translation of the Body Image in Pregnancy Scale (BIPS-G).

Background: This study aimed to provide a German translation of the Body Image in Pregnancy Scale (BIPS) - a measure tailored to pregnancy-specific aspects of body image while being consistent to the multifaceted theoretical framework of body image - and to test its psychometric properties and validity.

Methods: The English-language original version of the BIPS was translated into German language using a forward-backward translation rationale. Face validity of the items was tested in cognitive interviews (n = 5).

Living with outpatient management as spouse to intensively treated acute leukemia patients.

Background: Spouses have a key position in the treatment of patients with acute leukemia (AL) who are increasingly managed in an outpatient setting. Patients live at home but appear at the hospital every second day for follow-up visits. Patients must adhere to specific precautions due to an impaired immune system, which challenges and influence the life of the whole family.

Decomposition pathway of KAlH altered by the addition of AlS.

Altering the decomposition pathway of potassium alanate, KAlH4, with aluminium sulfide, Al2S3, presents a new opportunity to release all of the hydrogen, increase the volumetric hydrogen capacity and avoid complications associated with the formation of KH and molten K. Decomposition of 6KAlH4-Al2S3 during heating under dynamic vacuum began at 185 °C, 65 °C lower than for pure KAlH4, and released 71% of the theoretical hydrogen content below 300 °C via several unknown compounds. The major hydrogen release event, centred at 276 °C, was associated with two new compounds indexed with monoclinic (a = 10.

Disorder induced polymorphic transitions in the high hydrogen density compound Sr(BH)(NHBH).

The new compound Sr(BH4)2(NH3BH3)2 has been synthesized and characterized with in situ powder X-ray diffraction and fast (28 or 60 kHz) magic angle spinning 1H, 11B and 15N NMR and structurally optimized with density functional theory calculations. This investigation reveals complex structural rearrangements for this compound as a function of temperature. A room temperature orthorhombic polymorph, α-Sr(BH4)2(NH3BH3)2, with the space group symmetry Pbca, has been determined with a layered structure of alternating ammonia borane and Sr(BH4)2, partially stabilized by dihydrogen bonding.

Metal borohydrides and derivatives - synthesis, structure and properties.

A wide variety of metal borohydrides, MBH, have been discovered and characterized during the past decade, revealing an extremely rich chemistry including fascinating structural flexibility and a wide range of compositions and physical properties. Metal borohydrides receive increasing interest within the energy storage field due to their extremely high hydrogen density and possible uses in batteries as solid state ion conductors. Recently, new types of physical properties have been explored in lanthanide-bearing borohydrides related to solid state phosphors and magnetic refrigeration.

Thermal decomposition of sodium amide, NaNH, and sodium amide hydroxide composites, NaNH-NaOH.

Sodium amide, NaNH, has recently been shown to be a useful catalyst to decompose NH into H and N, however, sodium hydroxide is omnipresent and commercially available NaNH usually contains impurities of NaOH (<2%). The thermal decomposition of NaNH and NaNH-NaOH composites is systematically investigated and discussed. NaNH is partially dissolved in NaOH at T > 100 °C, forming a non-stoichiometric solid solution of Na(OH)(NH) (0 < x < ∼0.

Two Deafness-Causing Actin Mutations (DFNA20/26) Have Allosteric Effects on the Actin Structure.

Point mutations in γ-cytoplasmic actin have been shown to result in autosomal-dominant, nonsyndromic, early-onset deafness. Two mutations at the same site, K118M and K118N, provide a unique opportunity to compare the effects of two dissimilar amino acid substitutions that produce a similar phenotype in humans. K118 resides in a helix that runs from K113 to T126, and mutations that alter the position, dynamics, and/or biochemistry of this helix can result in a wide range of pathologies.

Short-term outcomes after complete mesocolic excision compared with 'conventional' colonic cancer surgery.

Background: Complete mesocolic excision (CME) seems to be associated with improved oncological outcomes compared with 'conventional' surgery, but there is a potential for higher morbidity.

Methods: Data for patients after elective resection at the four centres in the Capital Region of Denmark (June 2008 to December 2013) were retrieved from the Danish Colorectal Cancer Group database and medical charts. Approval from a Danish ethics committee was not required (retrospective study).

Synthesis and decomposition of Li3Na(NH2)4 and investigations of Li-Na-N-H based systems for hydrogen storage.

Previous studies have shown modified thermodynamics of amide-hydride composites by cation substitution, while this work systematically investigates lithium-sodium-amide, Li-Na-N-H, based systems. Li3Na(NH2)4 has been synthesized by combined ball milling and annealing of 3LiNH2-NaNH2 with LiNa2(NH2)3 as a minor by-product. Li3+xNa1-x(NH2)4 releases NaNH2 and forms non-stoichiometric Li3+xNa1-x(NH2)4 before it melts at 234 °C, as observed by in situ powder X-ray diffraction.

Outpatient management of intensively treated acute leukemia patients--the patients' perspective.

Purpose: In recent years, patients with acute leukemia (AL) have, to a greater extent, been managed in an outpatient setting where they live at home but appear every other day for follow-up visits at hospital. This qualitative article elucidates how patients with AL experience the different conditions of the inpatient and outpatient settings and how they reflect on these transitions in order to create meaning in and keep up everyday life.

Methods: Qualitative semi-structured individual interviews twice with each AL patient focusing on the outpatient setting, impact on everyday life, responsibility and the home were performed.

Ammine Calcium and Strontium Borohydrides: Syntheses, Structures, and Properties.

A new series of solvent- and halide-free ammine strontium metal borohydrides Sr(NH3 )n (BH4 )2 (n=1, 2, and 4) and further investigations of Ca(NH3 )n (BH4 )2 (n=1, 2, 4, and 6) are presented. Crystal structures have been determined by powder XRD and optimized by DFT calculations to evaluate the strength of the dihydrogen bonds. Sr(NH3 )(BH4 )2 (Pbcn) and Sr(NH3 )2 (BH4 )2 (Pnc2) are layered structures, whereas M(NH3 )4 (BH4 )2 (M=Ca and Sr; P21 /c) are molecular structures connected by dihydrogen bonds.

A composite of complex and chemical hydrides yields the first Al-based amidoborane with improved hydrogen storage properties.

The first Al-based amidoborane Na[Al(NH2 BH3 )4 ] was obtained through a mechanochemical treatment of the NaAlH4 -4 AB (AB=NH3 BH3 ) composite releasing 4.5 wt % of pure hydrogen. The same amidoborane was also produced upon heating the composite at 70 °C.