NBCn1 Increases NH Reabsorption Across Thick Ascending Limbs, the Capacity for Urinary NH Excretion, and Early Recovery from Metabolic Acidosis.

Background: The electroneutral Na/HCO cotransporter NBCn1 (Slc4a7) is expressed in basolateral membranes of renal medullary thick ascending limbs (mTALs). However, direct evidence that NBCn1 contributes to acid-base handling in mTALs, urinary net acid excretion, and systemic acid-base homeostasis has been lacking.

Methods: Metabolic acidosis was induced in wild-type and NBCn1 knockout mice.