Circulating tumour DNA and risk of recurrence in patients with asymptomatic versus symptomatic colorectal cancer.

Background: Multiple initiatives aim to develop circulating tumour DNA (ctDNA) tests for early cancer detection in asymptomatic individuals. The few studies describing ctDNA-testing in both asymptomatic and symptomatic patients report lower ctDNA detection in the asymptomatic patients. Here, we explore if asymptomatic patients differ from symptomatic patients e.

Impact of Whole Genome Doubling on Detection of Circulating Tumor DNA in Colorectal Cancer.

Objective: Circulating tumor DNA (ctDNA) is a candidate biomarker of cancer with practice-changing potential in the detection of both early and residual disease. Disease stage and tumor size affect the probability of ctDNA detection, whereas little is known about the influence of other tumor characteristics on ctDNA detection. This study investigates the impact of tumor cell whole-genome doubling (WGD) on the detection of ctDNA in plasma collected preoperatively from newly diagnosed colorectal cancer (CRC) patients.

Goal-directed fluid therapy in emergency abdominal surgery: a randomised multicentre trial.

Background: More than 50% of patients have a major complication after emergency gastrointestinal surgery. Intravenous (i.v.

[Gastric necrosis four years after fundoplication causing a dead foetus].

A 31-year-old pregnant woman was admitted and treated for diabetic ketoacidosis. As the patient deteriorated and the viability of the foetus was uncertain a CT scan was done which showed free fluid and air intraabdominally. Surgery was performed.

[Adenocarcinoma in the terminal ileum in a patient with no previous history of Crohn's disease].

We present a case of a 60-year-old man with no previous history of Crohn's disease who presented with abdominal pain and vomiting. X-ray examination of the abdomen showed obstructive ileus and the patient underwent emergency surgery. The resected terminal ileum was stenosed with characteristic changes of Crohn's disease.