Publications by authors named "Jeongha Mok"
Purpose: There have been efforts to find alternative samples other than standard samples of tissue or plasma for mutational analyses for lung cancer patients. However, no other sample or technique has replaced the mutational analyses using standard samples. In this prospective study, we assessed a novel bronchoscopy method, named as targeted washing technique, for detecting the EGFR mutation.
View Article and Find Full Text PDFPurpose: This study aimed to evaluate the prognosis of the not evaluated (NE) group by comparing it with the lost to follow-up (LTFU) group among patients with multidrug/rifampin-resistant tuberculosis (MDR/RR-TB).
Materials And Methods: This was a retrospective longitudinal follow-up study using an integrated database constructed by data linkage of the three national databases. This database included 7226 cases of MDR/RR-TB notified between 2011 and 2017 in South Korea.
Article Synopsis
- The study assessed the effectiveness of different sampling methods for next-generation sequencing (NGS) in lung cancer diagnostics, based on data from patients at Pusan National University Hospital.
- Overall, NGS yielded a high success rate of 97.5% across 319 patients, with no significant differences in DNA sequencing success between surgical (98%) and nonsurgical (96.4%) methods.
- However, surgical methods had a lower success rate for RNA sequencing (78%) compared to nonsurgical methods (92.3%), suggesting a need for improved protocols to mitigate RNA degradation during surgical sampling.
Article Synopsis
- The study investigated the effectiveness of patient-performed rapid antigen tests (RATs) in detecting COVID-19 variants Delta and Omicron during the pandemic, particularly in self-testing scenarios in Korea.
- Researchers conducted a multicenter clinical study involving participants without prior diagnostic experience and compared RAT results with the more accurate reverse transcriptase-polymerase chain reaction (RT-PCR) testing.
- Results showed that RATs were better at detecting the Omicron variant, while their performance for Delta was lower, especially among those who were only partially vaccinated, highlighting the need for careful use of these tests in different vaccination contexts.
Article Synopsis
- - The study investigated if a shorter, high-dose rifampicin treatment for tuberculosis is as effective as the standard 6-month regimen.
- - A total of 76 participants were enrolled, but the results showed a higher percentage of unfavorable outcomes in the investigational group compared to the control group, indicating the shorter regimen was not non-inferior.
- - Despite failing to prove non-inferiority, the shorter regimen did have a similar safety profile compared to the standard treatment.
Article Synopsis
- The study investigated death rates and predictors among patients with multidrug/rifampin-resistant tuberculosis (MDR/RR-TB) in South Korea from 2011 to 2017.
- Among 7,226 cases, 699 (9.7%) died within an average of 167 days of starting treatment, with significant differences in timing between TB-related and non-TB-related deaths.
- Key factors associated with higher mortality included older age, male sex, existing health conditions, low income, and specific TB characteristics, indicating high-risk groups that need targeted intervention to reduce mortality rates.
Article Synopsis
- This study explored factors impacting treatment success and culture conversion in pulmonary tuberculosis, emphasizing the use of AI-based chest X-ray analysis and Xpert MTB/RIF assay cycle threshold values.
- Out of 230 adult patients treated across six centers in South Korea, 206 (89.6%) successfully completed treatment, with significant correlations found between AI-based X-ray scores and both treatment success and culture conversion rates.
- The findings highlight that AI-based radiographic scoring at diagnosis could serve as a valuable predictor in managing tuberculosis treatment effectively.
This study explores the impact of QMAC-DST, a rapid, fully automated phenotypic drug susceptibility test (pDST), on the treatment of tuberculosis (TB) patients. This pre-post comparative study, respectively, included pulmonary TB patients who began TB treatment between 1 December 2020 and 31 October 2021 (pre-period; pDST using the Löwenstein-Jensen (LJ) DST (M-kit DST)) and between 1 November 2021 and 30 September 2022 (post-period; pDST using the QMAC-DST) in five university-affiliated tertiary care hospitals in South Korea. We compared the turnaround times (TATs) of pDSTs and the time to appropriate treatment for patients whose anti-TB drugs were changed based on these tests between the groups.
View Article and Find Full Text PDFBackground: Improving health-related quality of life (HRQOL) has emerged as a priority in the management of nontuberculous mycobacterial pulmonary disease (NTM-PD). We aimed to evaluate HRQOL and its changes after 6 months' treatment in patients with NTM-PD.
Methods: The NTM-KOREA is a nationwide prospective cohort enrolling patients initiating treatment for NTM-PD in 8 institutions across South Korea.
Bronchoscopic Strategies to Improve Diagnostic Yield in Pulmonary Tuberculosis Patients.
Tuberc Respir Dis (Seoul)
July 2024
In cases where pulmonary tuberculosis (PTB) is not microbiologically diagnosed via sputum specimens, bronchoscopy has been the conventional method to enhance diagnostic rates. Although the additional benefit of bronchoscopy in diagnosing PTB is well-known, its overall effectiveness remains suboptimal. This review introduces several strategies for improving PTB diagnosis via bronchoscopy.
View Article and Find Full Text PDFBackground And Objective: Next-generation sequencing (NGS) analysis is considered standard for lung cancer diagnosis in clinical practice. Little is known about the feasibility of NGS using tumour tissue sampled with a 1.1 mm-diameter cryoprobe.
View Article and Find Full Text PDFBackground/aims: To determine whether metformin, which is considered a host-directed therapy for tuberculosis (TB), is effective in improving the prognosis of patients with TB and diabetes mellitus (DM), who have higher mortality than those without DM.
Methods: This cohort study included patients who were registered as having TB in the National Tuberculosis Surveillance System. The medical and death records of matched patients were obtained from the National Health Information Database and Statistics Korea, respectively, and data from 2011 to 2017 were collected retrospectively.
Despite its significant impact on mortality, tuberculosis (TB)-diabetes mellitus (DM) co-prevalence has not been well-elucidated for the cause of death. We investigated the impact of DM on TB-related and non-TB-related deaths in patients with TB. This retrospective nationwide cohort study included patients diagnosed with TB between 2011 and 2017 in South Korea.
View Article and Find Full Text PDFPurpose: Isoniazid-monoresistant tuberculosis (Hr-TB) has emerged as a global challenge, necessitating detailed guidelines for its diagnosis and treatment. We aim to consolidate the Korean guidelines for Hr-TB management by gathering expert opinions and reaching a consensus.
Patients And Methods: A conventional Delphi method involving two rounds of surveys was conducted with 96 experts selected based on their clinical and research experience and involvement in nationwide tuberculosis studies and development of the Korean guidelines on tuberculosis.
Article Synopsis
- This study assessed mortality risk factors in patients with multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) in South Korea who were lost to follow-up (LTFU) between 2011 and 2017.
- Out of 7226 cases analyzed, 730 (10.1%) were LTFU, with a 4.2-year follow-up showing 101 deaths, mainly from non-TB-related causes.
- Key mortality risk factors identified included age, fluoroquinolone resistance, cancer, and lack of retreatment, highlighting that non-TB-related deaths could be mitigated through retreatment.
Objectives: Transbronchial cryobiopsy (TBCB) is a novel technique for the diagnosis of peripheral lung lesions (PLLs). We aim to evaluate the clinical outcomes of TBCB using a new 1.1-mm diameter cryoprobe for the diagnosis of PLLs.
View Article and Find Full Text PDFBackground: Effective treatment of fluoroquinolone-resistant multidrug-resistant tuberculosis (FQr-MDR-TB) is difficult because of the limited number of available core anti-TB drugs and high rates of resistance to anti-TB drugs other than FQs. However, few studies have examined anti-TB drugs that are effective in treating patients with FQr-MDR-TB in a real-world setting.
Methods: The impact of anti-TB drug use on treatment outcomes in patients with pulmonary FQr-MDR-TB was retrospectively evaluated using a nationwide integrated TB database (Korean Tuberculosis and Post-Tuberculosis).
Article Synopsis
- * Data from 837 patients in Korea helped establish a two-compartment PK model, identifying body weight and renal function as key factors affecting how EMB is cleared from the body.
- * Findings suggest specific dosing recommendations for different renal function groups to ensure optimal drug effectiveness, enhancing understanding of EMB's pharmacodynamics.
Background: The present study evaluated the association between participation in a rehabilitation program during a hospital stay and 1-year survival of patients requiring at least 21 days of mechanical ventilation (prolonged mechanical ventilation [PMV]) with various respiratory diseases as their main diagnoses that led to mechanical ventilation.
Methods: Retrospective data of 105 patients (71.4% male, mean age 70.
Objectives: This study aimed to identify the prevalence of diabetes mellitus (DM) among patients with tuberculosis (TB) using a nationwide cohort in South Korea.
Design: A retrospective cohort study.
Setting: This study used the Korean Tuberculosis and Post-Tuberculosis cohort, which was constructed by linking the Korean National Tuberculosis Surveillance, National Health Information Database (NHID) and Statistics Korea data for the causes of death.
Background/aims: Despite the obvious benefits of adding immune checkpoint inhibitors to platinum-etoposide chemotherapy in patients with extensive-stage small-cell lung cancer (ES-SCLC), real-world data remain scarce.
Methods: This retrospective study included 89 patients with ES-SCLC treated with platinum-etoposide chemotherapy alone (chemo-only group; n = 48) or in combination with atezolizumab (atezolizumab group; n = 41) and compared the survival outcomes between these two groups.
Results: Overall survival (OS) was significantly longer in the atezolizumab group than in the chemo-only group (15.
Background: The treatment outcomes of patients with multidrug/rifampin-resistant (MDR/RR) tuberculosis (TB) are important indicators that reflect the current status of TB management and identify the key challenges encountered by TB control programs in a country.
Methods: We retrospectively evaluated the treatment outcomes as well as predictors of unfavorable outcomes in patients with MDR/RR-TB notified from 2011 to 2017, using an integrated TB database.
Results: A total of 7,226 patients with MDR/RR-TB were included.
Objective: For thoracoscopy, the usefulness of a dye mixture of indigo carmine and Lipiodol for localizing lung lesions has been reported. However, little is known about the stability and safety of this dye mixture injected on the visceral pleura through a bronchoscope.
Methods: Porcine models were divided into three groups according to the detection time of the dye mixture: group A with a detection time of 4 h; group B, 8 h; and group C, 24 h.
Background: Multidrug-resistant tuberculosis (MDR-TB) represents a major public health concern, with an ongoing need for new effective treatments. Bedaquiline is an oral diarylquinoline that has shown encouraging treatment success and culture conversion rates in MDR-TB.
Methods: A South Korean patient registry was set up across 19 centres between 2016 and 2018 for the prospective collection of data from patients with MDR-TB who received either a bedaquiline-containing or a non-bedaquiline-containing regimen.