Prognostic Performance of the Next-Generation Sequencing-Based Multigene Assay in Early Breast Cancer Patients Treated According to the 21-Gene Assay Results.

Purpose: Multigene assays guide treatment decisions in early-stage hormone receptor-positive breast cancer. OncoFREE, a next-generation sequencing assay using 179 genes, was developed for this purpose. This study aimed to evaluate the concordance between the Oncotype DX (ODX) Recurrence Score (RS) and the OncoFREE Decision Index (DI) and to compare their performance.

Control of a Mechanical Blood Pump based on a Trade-off between Aortic Valve Dynamics and Cardiac Outputs.

Left ventricular assist device (LVAD) is a therapeutic option for advanced heart failure (HF) patients. This mechanical device assists a failing heart to circulate blood in the human body by adjusting its pump speed according to cardiac output. However, to use an LVAD for bridge-to-recovery, other criteria (e.

Propagation of Parametric Uncertainty in Aliev-Panfilov Model of Cardiac Excitation.

Models of cardiac electrophysiology are useful for studying heart functions and cardiac disease mechanisms. However, cardiac models often have a great level of complexity, and it is often computationally prohibitive to simulate tissue and organ activities in a real-time fashion. To address the challenge, simplified models such as Aliev-Panfilov model are developed to reduce model complexity, while providing necessary details of cardiac functions.