Differences in HbA at the time of diabetes diagnosis in the adult population of Ontario, Canada.

Aims: To determine the proportion of adults with HbA≥8.0% (64mmol/mol) at diabetes diagnosis, as an indicator of delayed diagnosis or less intensive screening.

Methods: We conducted a cross-sectional population-level study using clinical, administrative and immigration data from Ontario, Canada.

High Mobility Group A2 protects cancer cells against telomere dysfunction.

The non-histone chromatin binding protein High Mobility Group AT-hook protein 2 (HMGA2) plays important roles in the repair and protection of genomic DNA in embryonic stem cells and cancer cells. Here we show that HMGA2 localizes to mammalian telomeres and enhances telomere stability in cancer cells. We present a novel interaction of HMGA2 with the key shelterin protein TRF2.