Publications by authors named "Jeong-Soo Chang"
Synthesis of new ester prodrugs of olmesartan is described. Their in vitro stabilities in simulated gastric juice, rat plasma, and rat liver microsomes were tested. And the pharmacokinetic parameters for olmesartan after their oral administration were also estimated and compared with those in case of olmesartan medoxomil.
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- A study was conducted on new amides and esters prodrugs of olmesartan to assess their effectiveness.
- The ester derivative IIa was found to quickly convert into olmesartan in rat plasma, doing so within just 30 minutes.
- Pharmacokinetic analysis suggests that IIa could serve as a promising prodrug for olmesartan, potentially improving its therapeutic use.