Ceria-Incorporated Biopolymer for Preventing Fungal Adhesion.

Although biopolymers are widely used in biomedical fields, the issue of poor antimicrobial properties remains unsolved, leading to a potential increase in infections. Here, ceria nanoparticles (CNPs) were incorporated into a representative biopolymer, poly(methyl methacrylate) (PMMA), for drug-free antimicrobial properties. After characterizing the CNPs and surface/mechanical properties of the CNP-PMMA nanocomposite, antiadhesive effects against , the most common fungal species responsible for fungal infections, were determined using metabolic activity assays, and the underlying microbial antiadhesive mechanism was revealed.

Nano-graphene oxide incorporated into PMMA resin to prevent microbial adhesion.

Objective: Although polymethyl methacrylate (PMMA) is widely used as a dental material, a major challenge of using this substance is its poor antimicrobial (anti-adhesion) effects, which increase oral infections. Here, graphene-oxide nanosheets (nGO) were incorporated into PMMA to introduce sustained antimicrobial-adhesive effects by increasing the hydrophilicity of PMMA.

Methods: After characterizing nGO and nGO-incorporated PMMA (up to 2wt%) in terms of morphology and surface characteristics, 3-point flexural strength and hardness were evaluated.

Rechargeable microbial anti-adhesive polymethyl methacrylate incorporating silver sulfadiazine-loaded mesoporous silica nanocarriers.

Objectives: Even though polymethyl methacrylate (PMMA) resin is widely used as a dental material, it has poor microbial anti-adhesive properties, which accelerates oral infections. In this investigation, silver-sulfadiazine (AgSD)-loaded mesoporous silica nanoparticles (Ag-MSNs) were incorporated into PMMA to introduce long-term microbial anti-adhesive effects and to make PMMA a rechargeable resin.

Methods: After characterization of the Ag-MSNs in terms of their mesoporous characteristics and drug loading capacity, the 3 point flexural test and hardness were evaluated in PMMA incorporating Ag-MSNs (0.

Development of long-term antimicrobial poly(methyl methacrylate) by incorporating mesoporous silica nanocarriers.

Objective: Poly(methyl methacrylate) (PMMA) used as removable denture bases or orthodontic appliances has relatively poor antimicrobial properties, which accelerate oral infection and induce unfavorable odors. Mesoporous silica nanoparticles (MSNs) have been highlighted as a potential additive to overcome this issue because of their drug-loading capacity. Here, we present the long-term antimicrobial effect of MSN-incorporated PMMA with drug-loading capacity.