Publications by authors named "Jeong-Ju Yoo"
Background/aims: Direct-acting antivirals (DAAs) effectively eradicate hepatitis C virus (HCV). This study investigated whether metabolic dysfunction influences the likelihood of fibrosis regression after DAA treatment in patients with chronic hepatitis C (CHC).
Methods: This multicenter, retrospective study included 8,819 patients diagnosed with CHC who were treated with DAAs and achieved a sustained virological response (SVR) between January 2014 and December 2022.
Introduction: The combination of atezolizumab/bevacizumab has emerged as an effective first-line treatment for advanced hepatocellular carcinoma (HCC). However, this therapy is potentially associated with bleeding complications, warranting a comprehensive analysis of their incidence and severity. This meta-analysis aims to synthesize available evidence from clinical trials and observational studies to quantify the prevalence of bleeding following atezolizumab/bevacizumab administration.
View Article and Find Full Text PDFIntroduction And Objectives: The short-term mortality of severe alcoholic hepatitis (SAH) is high, but there are no effective treatments to improve short-term mortality other than corticosteroids. This study investigated the effects of adding rifaximin to standard treatment in patients with SAH.
Material And Methods: In this randomized controlled open-label trial, patients with SAH (Maddrey's discriminant function≥32) were randomized to the rifaximin or control group.
Immune checkpoint inhibitors (ICIs), which target immune checkpoints in cancer cells, are increasingly used as a mainstay in anticancer treatment. The combination of atezolizumab and bevacizumab is also a first-line treatment for hepatocellular carcinoma (HCC). However, ICIs can cause immune-related adverse events (IrAEs) which range from mild to severe, potentially leading to the need for discontinuing immunotherapy.
View Article and Find Full Text PDFBackground/aims: Non-alcoholic fatty liver disease (NAFLD), now the most common chronic liver worldwide, has become a significant public health concern. This study aims to analyze the evolving epidemiology of NAFLD in South Korea.
Methods: We utilized claim data from the Korean National Health Insurance Service from 2010 to 2022 to analyze NAFLD's incidence, prevalence, and progression.
Immune check inhibitor (ICI) colitis is one of most common and adverse side effects of ICI. However, there was no case report of ulcerative colitis (UC)-mimicking colitis after atezolizumab use in hepatocellular carcinoma (HCC) to our knowledge. We would like to introduce the case of a patient with Stage IV HCC who complained of abdominal pain, diarrhea and rectal bleeding after two cycles of atezolizumab/bevacizumab chemotherapy and was then diagnosed with UC-mimicking colitis.
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- Tenofovir alafenamide is a drug used to help people with HIV, but it may cause cholesterol levels to rise, which is a concern.
- Researchers looked at many studies to see how this drug affects cholesterol and fats in the blood.
- They found that people taking tenofovir alafenamide had increased cholesterol levels, but stopping the medication helped reduce those levels.
Article Synopsis
- The study explored the link between nonalcoholic fatty liver disease (NAFLD) and the risk of developing atrial fibrillation (AF), considering factors such as age and liver fibrosis.
- Researchers analyzed data from over 3 million participants, categorizing them based on their NAFLD status and identifying new cases of AF over a median follow-up of 9.3 years.
- The findings indicated that the risk of new-onset AF significantly increased with both the severity of NAFLD and the presence of advanced fibrosis, particularly among younger individuals aged 20-29.
Impacts of smoking on alcoholic liver disease: a nationwide cohort study.
Front Public Health
August 2024
Objectives: Smoking is a preventable risk factor for morbidity and mortality in patients with liver disease. This study aims to explore the additional risks of smoking in the development of alcoholic liver disease (ALD), cirrhosis, and hepatocellular carcinoma (HCC) in high-risk drinkers.
Methods: Data from the National Health Insurance Service, including claims and health check-up information spanning 2011 to 2017, were used.
Background: Atezolizumab/bevacizumab is emerging as the new standard for advanced hepatocellular carcinoma (HCC), with ongoing real-world implementation to study its effectiveness. As the use of atezolizumab/bevacizumab increases, various side effects have been reported in clinical practice, most notably increased bleeding caused by bevacizumab.
Case Summary: In this case report, we present a rare and fatal case of intratumoral hemorrhage in a patient with advanced HCC following successful treatment with atezolizumab/bevacizumab.
Article Synopsis
- A study explored the unclear relationship between diabetes and clinical outcomes in patients with alcoholic liver cirrhosis by analyzing data from 965 patients admitted due to acute decompensation from 2015 to 2019.* -
- Results showed that 23.6% of participants had diabetes, which correlated with increased risks for complications like hepatic encephalopathy and upper gastrointestinal bleeding. Notably, the incidence of death or liver transplantation was higher among diabetic patients.* -
- The findings concluded that diabetes significantly increases the risk of death or liver transplantation in these patients, leading to poorer health outcomes over time.*
Background: Laparoscopic liver resection (LLR) has been accepted as a safe and effective treatment for hepatocellular carcinoma (HCC). However, its impact on elderly patients remains uncertain. This study aimed to compare the efficacy and safety of LLR with open liver resection (OLR) in elderly HCC patients.
View Article and Find Full Text PDFBackground: There is a lack of national-level research on alcohol consumption and the epidemiology of alcoholic liver disease (ALD) in South Korea. This study aims to address the critical public health issue of ALD by focusing on its trends, incidence, and outcomes, using nationwide claims data.
Methods: Utilizing National Health Insurance Service data from 2011 to 2017, we calculated the population's overall drinking amount and the incidence of ALD based on ICD-10 diagnosis codes.
Purpose: To investigate urine microbiome differences among healthy women, women with recurrent uncomplicated cystitis (rUC), and those with sporadic/single uncomplicated cystitis (sUC) to challenge traditional beliefs about origins of these infections.
Materials And Methods: Patients who underwent both conventional urine culture and next-generation sequencing (NGS) of urine were retrospectively reviewed. Symptom-free women with normal urinalysis results as a control group were also studied.
Managing complications of liver cirrhosis such as varices needing treatment (VNT) and clinically significant portal hypertension (CSPH) demands precise and non-invasive diagnostic methods. This study assesses the efficacy of spleen stiffness measurement (SSM) using a 100-Hz probe for predicting VNT and CSPH, aiming to refine diagnostic thresholds. A retrospective analysis was conducted on 257 cirrhotic patients, comparing the diagnostic performance of SSM against traditional criteria, including Baveno VII, for predicting VNT and CSPH.
View Article and Find Full Text PDFBackground/aims: Bariatric intervention has been reported to be an effective way to improve metabolic dysfunction-associated steatotic liver disease (MASLD) in obese individuals. The current systemic review aimed to assess the changes in MRI-determined hepatic proton density fat fraction (MRI-PDFF) and nonalcoholic fatty liver disease activity score (NAS) after bariatric surgery or intragastric balloon/gastric banding in MASLD patients with obesity.
Methods: We searched various databases including PubMed, OVID Medline, EMBASE, and Cochrane Library.
Article Synopsis
- Childhood obesity is linked to a rising prevalence of nonalcoholic fatty liver disease (NAFLD) in kids and teens, yet systematic studies on this issue are scarce.
- A comprehensive search of multiple databases yielded 62 relevant studies for analysis, revealing that NAFLD affects 13% of the general pediatric population and 47% of obese kids.
- The study found significant gender differences in prevalence, with higher rates in males than females for both general and obese populations, highlighting the urgent need for more epidemiological research on NAFLD in pediatrics.
Validation of MELD 3.0 in patients with alcoholic liver cirrhosis using prospective KACLiF cohort.
J Gastroenterol Hepatol
September 2024
Background And Aim: The Model for End-Stage Liver Disease (MELD) is a reliable prognostic tool for short-term outcome prediction in patients with end-stage liver disease. MELD 3.0 was introduced to enhance the predictive accuracy.
View Article and Find Full Text PDFBackground/aims: : With increased life expectancy, the management of elderly hepatocellular carcinoma (HCC) patients became a crucial issue, yet it is still challenging due to comorbidities and high surgical risks. While surgical resection is considered as primary treatment for eligible HCC patients, systematic evidence on its outcomes in elderly patients remains scarce. In this review, we aimed to analyze the efficacy and safety outcomes of surgical resection in elderly HCC patients.
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- A study was conducted to explore the relationship between serum gamma-glutamyl transferase (GGT) levels and mortality rates in patients with type 2 diabetes, utilizing a large Korean health-screening database.
- Out of nearly 10 million participants observed over an average of 8.1 years, higher GGT levels were linked to increased all-cause mortality and specific causes of death, such as cardiovascular diseases, cancer, and liver disease.
- The findings suggest that measuring serum GGT levels could be beneficial for evaluating mortality risk in individuals with type 2 diabetes.
Article Synopsis
- The study evaluated a modified version of the quick sequential organ failure assessment (m-qSOFA) to identify high-risk patients with deteriorating chronic liver disease, particularly those with acute-on-chronic liver failure.
- Patients with a high m-qSOFA score had significantly lower transplant-free survival rates and higher organ failure development compared to those with low scores across two different cohorts.
- The findings suggest that both initial m-qSOFA scores and changes over time can help predict the risk of organ failure and short-term mortality in patients with acute deterioration of liver disease.
Article Synopsis
- * Racial and ethnic differences add complexity to understanding HCC epidemiology, emphasizing the need for tailored approaches to risk prediction across various populations.
- * This study focuses on evaluating the effectiveness of the Texas hepatocellular carcinoma risk index (THCC-RI), originally created for Western populations, in predicting HCC risk in an Eastern context.