Publications by authors named "Jeong-Hyun Lee"

Radiofrequency ablation (RFA) is a minimally invasive treatment modality used as an alternative to surgery in patients with benign thyroid nodules, recurrent thyroid cancers (RTCs), and primary thyroid microcarcinomas. The Korean Society of Thyroid Radiology (KSThR) initially developed recommendations for the optimal use of RFA for thyroid tumors in 2009 and revised them in 2012 and 2017. As new meaningful evidence has accumulated since 2017 and in response to a growing global interest in the use of RFA for treating malignant thyroid lesions, the task force committee members of the KSThR decided to update the guidelines on the use of RFA for the management of RTCs based on a comprehensive analysis of current literature and expert consensus.

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This study aims to investigate the three-dimensional morphological differences of the sphenoid sinus according to sex in the Korean adult population and conduct an exploratory study based on the findings. The sphenoid sinus, located deep within the skull, plays a crucial role in forensic identification due to its relative protection from external damage and its unique anatomical characteristics. Using cone-beam computed tomography (CBCT) data from 120 patients (60 males and 60 females) aged 20-29, the sphenoid sinus was visualized and measured in three dimensions using Mimics software (version 22.

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This study assessed the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treatment of skin-involving recurrent thyroid cancer. In this retrospective case series study, 43 patients (mean age: 67.9 ± 14.

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Background: This study aimed to assess the significance of elevated carbohydrate antigen (CA) 19-9 in postoperative surveillance of extrahepatic bile duct cancer and to identify short-term recurrence predictors.

Methods: This retrospective study included patients with elevated CA 19-9 post-curative surgery. Patients were categorized into positive and negative CT groups based on the detection of recurrence at CA 19-9 elevation.

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  • The study aimed to assess the real-world effectiveness of brolucizumab injections for patients with neovascular age-related macular degeneration (nAMD) who did not respond to previous treatments.
  • Results showed that while visual acuity (BCVA) remained stable, anatomical improvements were noted, such as decreased central foveal thickness (CFT) and reduced presence of subretinal fluid (SRF) and pigment epithelial detachment (PED) after switching to brolucizumab.
  • The safety profile was acceptable, with a low incidence of intraocular inflammation-related adverse events reported among the patients.
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  • Autotaxin (ATX) is being targeted for new liver disease treatments, and drug candidates were identified through high-throughput screening methods.
  • Researchers synthesized a small molecule called KR-40795, designed to inhibit ATX's activity by binding to specific regions of the enzyme.
  • KR-40795 effectively reduced collagen formation and lipid accumulation in liver cells, showcasing its potential to treat liver conditions like fibrosis and steatosis.
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Introduction: Cataract surgery is one of the most commonly performed surgical procedures worldwide. Intraoperative and postoperative complications of cataract surgery include posterior capsule rupture, retinal detachment, suprachoroidal hemorrhage, cystoid macular edema, endophthalmitis, and intraocular lens dislocation. As corneal perforation is rarely related to cataract surgery, we report a case of intraoperative iatrogenic corneal puncture that led to a full-thickness laceration that was managed without severe complications.

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Background/objectives: Nasal morphology is a significant aspect of facial anatomy and is often used for forensic identification and aesthetic surgery. This study aims to compare nasal dimensions based on sex, facial index (FI), and nasal index (NI) using cone-beam computed tomography (CBCT) and 3D modeling.

Methods: To observe differences in nasal dimensions by sex and analyze the relationships between facial shapes (FI) and nasal forms (NI), a total of 100 participants (50 males, 50 females) in their 20s were selected from Dankook University Dental Hospital.

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  • * Recent research highlights the potential of plant-derived extracellular vesicles (EVs), such as those from red cabbage (Rabex), which are economical and have multiple beneficial biological effects.
  • * Engineered red cabbage EVs (t-Rabex) demonstrate improved targeting of intestinal cells and enhanced therapeutic effects, showing promise for treating IBD through anti-inflammatory and regenerative functions.
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Objective: This study investigates the long-term efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating locally recurrent papillary thyroid cancer (PTC).

Materials And Methods: We retrospectively analyzed 39 consecutive patients with 61 locally recurrent PTCs (14 males, 25 females; mean ± standard deviation age, 52.8 ± 16.

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  • The study aimed to investigate whether switching gadolinium-based contrast agents (GBCAs) can help reduce the recurrence of acute adverse drug reactions (ADRs) associated with their use during MRI exams.
  • From nearly 239,000 MRI exams between January 2016 and December 2021, 1,042 cases of acute ADRs were identified, with follow-up evaluations showing a recurrence rate of 31.9% among patients who experienced ADRs.
  • Results indicated that patients who switched to different GBCAs had a significantly lower recurrence of ADRs (14.3%) compared to those who remained on the same agent (36.9%), suggesting that changing
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  • Severe fever with thrombocytopenia syndrome (SFTS) has a high mortality rate, especially in immunocompromised patients, often leading to severe encephalitis symptoms before death.* -
  • The SFTS virus (SFTSV) infects critical areas of the brain like the brainstem and spinal cord, resulting in respiratory and motor nerve issues.* -
  • Activated A1-reactive astrocytes in infected mice cause neuronal cell death and neuroinflammation, suggesting a potential target for future SFTS treatments, as there are currently no effective therapies.*
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Objectives: To compare microvascular flow imaging (MVFI) and power Doppler ultrasonography imaging (PDUS) for detecting intratumoral vascularity in recurrent thyroid cancer both before and after radiofrequency ablation (RFA).

Methods: This retrospective study included 80 patients (age, 57 ± 12 years; 54 women) with 110 recurrent tumors who underwent RFA between January 2021 and June 2023. A total of 151 PDUS and MVFI image sets were analyzed (85 pre-RFA, 66 post-RFA).

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Longer follow-up after radiofrequency ablation (RFA) of benign thyroid nodules is needed to understand regrowth and other causes of delayed surgery and long-term complications. This retrospective study included consecutive patients treated with RFA for symptomatic benign nonfunctioning thyroid nodules between March 2007 and December 2010. RFA was performed according to the standard protocol.

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Objectives: To investigate the diagnostic performance and interobserver agreement of quantitative CT parameters indicating strong lymph node (LN) enhancement in differentiated thyroid cancer (DTC), comparing them with qualitative analysis by radiologists of varying experience.

Materials And Methods: This study included 463 LNs from 399 patients with DTC. Three radiologists independently analyzed strong LN enhancement on CT.

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Background/aim: NUAK family kinase 2 (NUAK2) is a promising target for cancer therapeutics due to its reported role in protein phosphorylation, a critical process in cancer cell survival, proliferation, invasion, and senescence. This study aimed to identify novel inhibitors that disrupt NUAK2 activity. We have already identified two KRICT Hippo kinase inhibitor (KHKI) compounds, such as KHKI-01128 and KHKI-01215.

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A key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of priming immunogens that induce rare bnAb-precursor B cells. The high neutralization breadth of the HIV bnAb 10E8 makes elicitation of 10E8-class bnAbs desirable; however, the recessed epitope within gp41 makes envelope trimers poor priming immunogens and requires that 10E8-class bnAbs possess a long heavy chain complementarity determining region 3 (HCDR3) with a specific binding motif. We developed germline-targeting epitope scaffolds with affinity for 10E8-class precursors and engineered nanoparticles for multivalent display.

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Purpose: To identify high-risk computed tomography (CT) features for predicting gallbladder (GB) cancer in patients presenting with localized GB wall thickening.

Methods: This retrospective analysis included 120 patients (mean age: 63.9 ± 10.

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  • The study assessed how preoperative MRI characteristics influence the outcomes of patients with large single hepatocellular carcinoma (HCC) undergoing surgery.
  • It analyzed data from 151 patients, focusing on tumor size, margins, and the degree of hypovascularity during MRI, finding that factors like larger tumor size and greater hypovascularity were linked to worse survival rates.
  • The results highlighted the need for careful management in patients with specific MRI findings, indicating that these features could help tailor treatment strategies post-surgery.
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A protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with AS01 was found to induce VRC01-class bnAb precursors in 97% of vaccine recipients in the IAVI G001 phase 1 clinical trial; however, heterologous boost immunizations with antigens more similar to the native glycoprotein will be required to induce bnAbs. Therefore, we designed core-g28v2 60mer, a nanoparticle immunogen to be used as a first boost after eOD-GT8 60mer priming.

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Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the recruitment of memory B cells (MBCs) to germinal centers (GCs) is inefficient and may be derailed by serum antibody-induced epitope masking, driving further B cell receptor (BCR) modification in GC-experienced B cells after boosting poses a challenge. Using humanized immunoglobulin knockin mice, we found that GT protein trimer immunogen N332-GT5 could prime inferred-germline precursors to the V3-glycan-targeted bnAb BG18 and that B cells primed by N332-GT5 were effectively boosted by either of two novel protein immunogens designed to have minimum cross-reactivity with the off-target V1-binding responses.

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