SCL-90-R and 16PF profiles of senior high school students with excessive internet use.

Objective: To investigate the psychiatric symptomatology and personality characteristics of Korean senior high school students considered to use the Internet to excess.

Method: We administered a questionnaire packet to students that included 4 measures. These measures included a questionnaire on Internet use patterns during the previous month, the Internet Addiction Test (IAT), the Symptom Checklist-90-R (SCL-90-R), and the Sixteen Personality Factor Questionnaire (16PF).

Age-related changes in sleep/wake patterns among Korean teenagers.

Introduction: As children go through the transition from childhood to adolescence, many shifts occur in sleep/wake patterns related to intrinsic and extrinsic developmental changes. These shifts have been shown to result in corresponding shifts in sleep phase (later sleep onset) and sleep deprivation among teenagers in Western societies. However, the effect of these developmental changes on the sleep habits of Korean teenagers has not been analyzed.

Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs.

In the search for new naturally occurring anti-angiogenic compounds, we found that a culture broth of an unidentified fungal strain B90911 exerted inhibitory activity on capillary-like tube formation of human umbilical vein endothelial cells (HUVEC) in vitro. Four active compounds were isolated by bioassay-guided separation and their structures were identified to be sulochrin (1), methyl asterric acid (2), and two new asterric acid derivatives, 3-chloroasterric acid (3), and 3,5-dichloroasterric acid (4) by spectroscopic analyses. These compounds significantly inhibited the VEGF-induced tube formation of HUVEC, suggesting that asterric derivatives could be useful for further study as anti-angiogenic agents.