Publications by authors named "Jeong-Hwan Shin"

Two Gram-stain-negative cocci anaerobes were isolated from pig faeces and designated as strains YH-vei2232 and YH-vei2233. Phylogenetic analysis using 16S rRNA gene sequences revealed that the isolates were most closely related to KCTC 5967, with 97.0% similarity.

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Article Synopsis
  • A new bacterium strain, named YH-ols2223, was isolated from pig feces and is classified as a short-rod, Gram-positive, obligate anaerobe.
  • Genetic analysis shows it has 97.7% similarity to KCTC 25755 and forms a unique sub-cluster within its genus.
  • The bacterium produces lactic and acetic acids during fermentation and has a distinctive peptidoglycan structure, leading to its designation as a novel species.
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Introduction: The rapid spread of COVID-19 worldwide within 2 months demonstrated the vulnerability of the world's population to infectious diseases. In 2015, the Global Antimicrobial Resistance and Use Surveillance System (GLASS) was launched to combat antimicrobial resistance (AMR). However, there has been no comprehensive assessment of the decade-long global battle against AMR based on GLASS data.

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Background: This study analyzed the genetic traits and fitness costs of vancomycin-resistant Enterococcus faecium (VREfm) blood isolates carrying Tn1546-type transposons harboring the vanA operon.

Methods: All E. faecium blood isolates were collected from eight general hospitals in South Korea during one-year study period.

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Background: Healthcare 4.0. refers to the integration of advanced technologies, such as artificial intelligence (AI) and big data analysis, into the healthcare sector.

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  • Two novel bacteria, YH-ols2216 and YH-ols2217, were isolated from pig feces, identified as rod-shaped, obligate anaerobic, and Gram-positive, showing high genetic similarity to related species.* -
  • The genetic analysis revealed significant similarities (92.0-92.5%) with other strains, while the isolates showed 99.9% similarity to each other, leading to the proposal of a new family and genus based on various chemotaxonomic and phenotypic properties.* -
  • Key characteristics included lactate as the main end-product, specific fatty acids in their cell membranes, and high DNA G+C content, supporting their classification as a novel taxon within the bacterial
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  • - Two new strains of bacteria, YH-aer221 and YH-aer222, were discovered in pig feces and are similar to the known strain JCM 18035 with over 96% genetic similarity.
  • - Various genetic analyses, including average nucleotide identity and digital DNA-DNA hybridization, confirmed their distinct status with low similarity to other bacteria, indicating they belong to a new category.
  • - The bacteria possess unique features like a specific fatty acid profile and shared metabolic pathways, and both isolates have the same CRISPR array, leading to the proposal of a new species name.
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Background: We compare the diversity and niche specificity of the microbiome in the trachea-oropharynx microbiome of malignant breast neoplasm with or without neoadjuvant chemotherapy (NAC) NGS analysis.

Methods: We prospectively collected a total of 40 endotracheal tubes intubated from subjects, of whom 20 with NAC treated breast cancer (NAC group) and 20 with breast cancer without NAC (Non-NAC group). We generated 16S rRNA-based microbial profiles in IlluminaTM platform and alpha diversity indices were compared between groups.

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Objectives: The purpose of this study is to evaluate the usefulness of anaerobic blood culture in pediatric patients by comparing the detection rate and distribution of bacteria between aerobic and anaerobic blood culture bottles.

Methods: A retrospective analysis was conducted on 11,664 blood cultures obtained from children under the age of 14 between January 2013 and June 2020. The positive rate of total, aerobic, and anaerobic blood culture, as well as the species distribution of each blood culture bottle, were investigated.

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  • The Lachnospiraceae family, associated with gut health and obesity, includes the newly identified isolate YH-rum2234, found in pig feces, which is an obligately anaerobic bacterium.
  • A polyphasic taxonomic approach was used to analyze this isolate, revealing significant genetic differences from closely related strains, with a 94.3% similarity to Lientehia hominis.
  • Based on its unique characteristics, YH-rum2234 is classified as a new genus and species named Fusibacillus kribbianus.
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is known as a probiotic butyric acid bacterium that can improve the intestinal environment. In this study, we isolated a new strain of from infant feces and evaluated its physiological characteristics and antiviral efficacy by modulating the innate immune responses and . The isolated S-45-5 showed typical characteristics of including bile acid resistance, antibacterial ability, and growth promotion of various lactic acid bacteria.

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  • - A new rod-shaped, aerotolerant, Gram-positive bacterium, named strain YH-lim2214, was isolated from pig feces and is closely related to KCTC 25258 with 98.0% 16S rRNA gene similarity.
  • - The genetic comparison shows 81.4% average nucleotide identity and 81.3% average amino acid identity between YH-lim2214 and KCTC 25258, indicating a significant relationship.
  • - The strain exhibits unique chemotaxonomic and phenotypic properties, with a specific peptidoglycan type and G+C content, leading to the proposal of it as a new species in microbiology.
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Objective: The genus Hallella was described within Bacteroidaceae, and then reclassified within Prevotellaceae based on its phenotypic and phylogenetic description. It is associated with degradation of carbohydrate. However, some species of Hallella have pathobiotic properties, and are involved in infections and chronic inflammatory disorders.

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A lactic acid bacterium isolated from pig faeces was characterized using a polyphasic approach. The strain was Gram-stain-positive, rod-shaped, and facultative anaerobic. Phylogenetic analysis of the 16S rRNA gene sequence indicated that the isolate belonged to the genus .

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A lactic acid bacteria isolated from pig faeces was characterized using a polyphasic approach. Cells of the strain were Gram-stain-positive, rod-shaped and facultative anaerobic. Phylogenetic analysis of 16S rRNA gene sequence indicated that the isolate belonged to the genus ; however, the similarity to other homologues within the genus was <98 %.

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  • - The study focuses on developing a fast and accurate screening test for urinary tract infections (UTIs) using the UF-5000, with the goal of improving diagnosis and reducing the time taken for test results.
  • - Researchers analyzed 1,063 urine samples and found that a BACT count above 685.3/µL provided the best diagnostic accuracy, boasting 93.8% sensitivity and 90.2% specificity for UTI detection.
  • - The findings suggest that using both the BACT count and the BACT-Info flag together enhances UTI diagnosis, particularly for Gram-negative bacteria, making it beneficial for guiding empirical treatment options.
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is a major pathogen causing foodborne infections in humans. Salmonella isolates are identified using biochemical and serological tests, including automated systems such as the VITEK2 system. However, there are few reports on identification using VITEK MS.

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  • The Kor-GLASS system integrated nationwide antifungal surveillance for Candida species, examining data from nine hospitals in Korea during 2020-2021.
  • A significant percentage (87.6%) of Candida blood isolates were from hospital settings, with older adults (over 60) making up the majority (75.7%) of cases and many patients originating from intensive care units.
  • Resistance to antifungal medications like fluconazole and voriconazole was observed in a portion of the isolates, highlighting the importance of enhancing surveillance to tackle Candida infections globally.
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Imipenemase (IMP)-6-producing sequence type (ST) 235 is a dominant clone of carbapenemase-producing (CPPAE) in Korea. As part of the Antimicrobial Resistance Surveillance System in Korea, we found an increase in the carbapenem resistance rate of isolates from blood cultures and a shift in the molecular epidemiology of CPPAE. A total of 212 non-duplicated blood isolates were obtained from nine general hospitals and two nursing homes.

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  • The study analyzed invasive pneumococcal disease (IPD) strains in Korea after the introduction of the pneumococcal conjugate vaccine (PCV13), focusing on serotype distribution and antimicrobial resistance.
  • Among the 411 isolates tested, serotype 3 was the most common, with notable antimicrobial resistance rates, especially for erythromycin (80.3%) and penicillin (13.1%).
  • The findings highlight an increase in non-PCV13 serotypes and multidrug-resistant (MDR) strains, indicating a need for ongoing monitoring to effectively manage and treat infections.
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Escherichia coli is responsible for more than 80% of all incidences of urinary tract infections (UTIs). We assessed a total of 636 cases of patients with E. coli UTIs occurring in June 2019 in eight tertiary hospitals in South Korea for the traits of patients with E.

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Background: The spread of carbapenem-resistant (CRE) strains has caused treatment failure and is a worldwide threat to public health. However, there are limited reports on the prevalence of carbapenemase-producing (CPE) in aquatic environments and its association with clinical isolates. This study aimed to investigate the prevalence of CPE in a stream environment and its genetic relationship with clinical isolates in Korea.

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We used a Vitek 2 AST-YS08 (YS08) system and the broth microdilution method (BMD) adopted by the Clinical and Laboratory Standards Institute (CLSI) to compare the susceptibility of 184 isolates of 11 species to fluconazole, voriconazole, micafungin, caspofungin, amphotericin B, and flucytosine. In Candida albicans, the categorical agreement (CA) was 79.2%, 91.

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