Publications by authors named "Jeong-Hun Seo"

Background: Aortic valve sclerosis (AVS) shares risk factors with atherosclerosis. However, the relationship between AVS progression with cardiovascular (CV) risk has not been researched. This study investigates CV outcomes according to progression of AVS.

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Background: Little research has been assessed atherosclerotic risk factors at various stages of calcific aortic valve disease. This study sought to determine risk factors of patients with aortic valve sclerosis (AVS) and mild to moderate aortic stenosis (AS).

Methods: The study included 1,007 patients diagnosed with AVS or mild to moderate AS according to echocardiographic criteria.

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Article Synopsis
  • A nationwide study in Korea analyzed treatment patterns and survival rates of pancreatic cancer from 2006 to 2019, based on data from 78,920 patients.
  • The findings revealed that a significant portion of patients received supportive care only, while those undergoing surgery or chemotherapy experienced increased survival, with median survival improving from 5.5 months to 9.8 months over the years.
  • Younger patients showed the most notable survival improvements, highlighting a trend toward more aggressive treatments for pancreatic cancer over the past decade.
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Background: We investigated the short- and long-term risks of pancreatic cancer after the diagnosis of acute pancreatitis.

Methods: This population-based matched-cohort study used data from the Korean National Health Insurance Service database. Patients with acute pancreatitis (n = 25,488) were matched with the control group (n = 127,440) based on age, sex, body mass index, smoking status, and diabetes.

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Background: Few studies have focused on computed tomography findings before a pancreatic cancer diagnosis. We aimed to investigate the prediagnostic computed tomography findings of patients who had undergone computed tomography within the prediagnostic period of their pancreatic cancer diagnosis.

Methods: Between January 2008 and December 2019, 27 patients who underwent contrast-enhanced abdominal or chest computed tomography including the pancreas within 1 year of a pancreatic cancer diagnosis were enrolled in this retrospective study.

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Aims: The pressure increase per time unit (dP/dt) in aortic stenosis (AS) jet velocity is assumed to have inter-individual variability in the progressive AS stage. We sought to examine the association of aortic valve (AoV) Doppler-derived dP/dt in patients with mild to moderate AS with risk of progression to severe disease.

Methods And Results: A total of 481 patients diagnosed with mild or moderate AS [peak aortic jet velocity (Vmax) between 2 and 4 m/s] according to echocardiographic criteria were included.

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Background Recently, diastolic stress testing and invasive hemodynamic measurements have been emphasized for diagnosis of heart failure with preserved ejection fraction (HFpEF) because when determined using noninvasive parameters it can fall into a nondiagnostic intermediate range. The current study evaluated the discriminative and prognostic roles of invasive measured left ventricular end-diastolic pressure in the population with suspected HFpEF, particularly for patients with intermediate Heart Failure Association Pre-test Assessment, Echocardiography & Natriuretic Peptide, Functional Testing, Final Etiology (HFA-PEFF) score. Methods and Results A total of 404 patients with symptoms or signs of HF and preserved left ventricular systolic function were enrolled.

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Background: The left atrium (LA) plays an important role in the pathophysiology and disease progression of heart failure with preserved ejection fraction (HFpEF).

Objectives: This study sought to assess the prognostic potential of LA stiffness index in patients who have HFpEF.

Methods: This study retrospectively screened patients with elevated left ventricular end-diastolic pressure (≥16 mm Hg) and preserved ejection fraction (≥50%) between January 1, 2004, and December 31, 2019.

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Background: The prognostic role of myocardial ischemia in patients with heart failure with preserved ejection fraction (HFpEF) has not been fully elucidated. Therefore, we investigated the change in echocardiographic parameters and clinical outcomes based on the presence of epicardial coronary artery disease (CAD) and positive stress tests in HFpEF patients.

Methods: Symptomatic patients with left ventricular end diastolic pressure ≥15 mmHg who underwent coronary angiography were analyzed between January 2000 and August 2019 after exclusion of patients with acute coronary syndrome.

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Aims: Tricuspid valve (TV) surgery for functional tricuspid regurgitation (TR) is becoming more common, but the associated mortality remains high. Therefore, we evaluated the clinical and echocardiographic parameters associated with all-cause mortality in patients with severe functional TR who underwent TV surgery.

Methods And Results: A total of 286 patients with severe functional TR who underwent TV replacement or repair was analysed between January 2006 and December 2017.

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Article Synopsis
  • Ginsenosides, key components of ginseng, were studied for their ability to modulate immune responses, specifically through a ginseng product called GBCK10S made from enzymatic bioconversion.
  • The study involved testing GBCK10S on mice and a human NK cell line to assess its effects on immune markers and cell activities using various scientific methods.
  • Results showed that GBCK10S boosted levels of specific immune proteins and activated natural killer cells, suggesting it has strong potential to enhance immune response mediated by different types of immune cells.
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Background: Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer.

Methods: Using the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017.

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The autonomic nervous system (ANS) plays an important role in the initiation and maintenance of atrial fibrillation (AF). However, the meaning of higher heart rate variability (HRV) in predicting AF remains unclear. Among 2100 patients in the Holter registry, a total of 782 hypertensive patients were included in this study.

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Background: Recurrence of any atrial arrhythmia after surgical ablation is known as a negative predictor of cardiovascular events and total mortality. However, there have been no focused studies for atrial fibrillation (AF) recurrence prediction in patients with significant tricuspid regurgitation (TR), and the risk-benefit estimation of surgical ablation in tricuspid valve (TV) surgery is not fully established.

Method: We screened 385 patients who underwent a TV operation between 2001 and 2017.

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Background: Total ischemic time (TIT) is an important factor for predicting mortality among patients with ST-segment elevation myocardial infarction (STEMI). However, the correlation between TIT and the extent of wall motion abnormality has not been well studied. Therefore, we investigated changes in the wall motion score index (WMSI) value based on TIT in STEMI patients who underwent primary percutaneous coronary intervention (PCI) and subsequent transthoracic echocardiography.

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  • Plant tissue culture can be used to produce secondary metabolites that may have therapeutic benefits, particularly in treating skin issues like photoaging and pigmentation.
  • Researchers tested the effects of callus pellet extract (AYC-P-E) on melanogenesis in B16F10 melanoma cells after inducing excessive melanin production.
  • AYC-P-E showed a significant inhibition of melanin production in cell studies and led to measurable improvements in skin pigmentation in clinical trials, linked to the activation of specific signaling pathways (MEK/ERK and AKT).
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Type 2 diabetes (T2D) is a threaten human health problem, and accompanied by hyperglycemia and disorder of insulin secretion, is a major cause of abnormalities in maintaining blood glucose homeostasis. Also, low-grade inflammation, as well as insulin resistance (IR), is a common feature in patients with T2D. Numerous causes of the outbreak of T2D have been suggested by researchers, who indicate that genetic background and epigenetic predisposition, such as overnutrition and deficient physical activity, hasten the promotion of T2D milieu.

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  • The extract has demonstrated multiple health benefits, including anti-inflammatory and antioxidant effects, but its commercial production is time-consuming and environmentally challenging.
  • Researchers are developing a bioreactor system to produce the extract rapidly from cultured callus to test its efficacy against photoaging in skin cells exposed to UVB light.
  • The study identified 17 key metabolites in the extract that significantly enhance skin cell recovery, collagen production, and moisture retention while mitigating inflammation associated with skin damage from UVB exposure, indicating its potential as a cosmetic ingredient.
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Ginseng (Panax ginseng) is commonly used in Asia as a medicinal herb. In particular, fermented ginseng, GBCK25, has been recently developed to increase ginsenoside absorption. It also has other beneficial biological effects such as hemodynamic and anti-inflammation functions.

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Ethnopharmacological Relevance: Orostachys japonicus A. Berger (O. japonicus), referred to as Wa-song in Korea is a traditional and herbal medicine.

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Aims: Although some peripartum-associated cardiomyopathy patients present with features that are clinically and echocardiographically similar to those of takotsubo cardiomyopathy (TCM), little is known about the diagnosis and clinical course of peripartum TCM.

Methods And Results: In a tertiary hospital in Seoul, Korea, we searched the hospital database to find cardiomyopathy cases that were associated with pregnancy from January 1995 to May 2019. Applying the published diagnostic criteria, we sought peripartum cardiomyopathy (PPCM) and peripartum TCM patients for comparison.

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Very few population-based studies have examined the epidemiology of Wilson's disease (WD). We investigated the epidemiology of WD using the National Health Insurance Service (NHIS) database in South Korea. We analyzed not only the statistical variables of WD, but also those of WD-related diseases.

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Article Synopsis
  • * Researchers reviewed the medical records of 192 patients and found that 76.6% had identifiable causes for their elevated CA 19-9, including hepatic, pulmonary, gynecologic, endocrine, and spleen diseases.
  • * The study concludes that patients with elevated CA 19-9 should be systematically evaluated to determine the cause, with a proposed algorithm for comprehensive follow-up to manage these cases effectively.
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Background: Recently, clinical research has suggested that red ginseng components play a role in liver protection and combating fatigue. However, fermented ginseng has not been analyzed for liver-protective or anti-fatigue effects.

Objective: This study evaluates the positive effects of fermented ginseng powder (GBCK25) on liver function.

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