Publications by authors named "Jeong Yoon"

Objective: To compare the image quality and lesion conspicuity of conventional vs deep learning (DL)-based reconstructed three-dimensional T1-weighted images in gadoxetic acid-enhanced liver magnetic resonance imaging (MRI).

Methods: This prospective study (NCT05182099) enrolled participants scheduled for gadoxetic acid-enhanced liver MRI due to suspected focal liver lesions (FLLs) who provided signed informed consent. A liver MRI was conducted using a 3-T scanner.

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  • - The study evaluated the effectiveness of virtual monoenergetic images (at 50 keV) from dual-layer spectral CT (DLSCT) in detecting colorectal liver metastasis (CRLM) compared to standard iDose images, using a sample of 173 patients.
  • - Findings revealed that 50 keV images had higher rates of lesion detection (45% vs. 40%) and better visibility of CRLMs, but lower specificity for diagnosis (94.5% vs. 96%) and more indeterminate lesions.
  • - In conclusion, while 50 keV images showed superior detection and visibility of CRLM, they did not significantly enhance diagnostic accuracy, indicating a trade-off between detection and specificity. *
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Importance: Although optic disc hemorrhage (DH) is widely recognized as a glaucoma risk factor, its clinical relevance in relation to proximity has not been investigated.

Objective: To determine the association of the proximal location of DH with glaucoma progression.

Design, Setting, And Participants: In this longitudinal observational cohort study, 146 eyes of 146 patients at Seoul National University Hospital who had had 1 or more DH with at least 5 years of follow-up and had at least 5 reliable visual field examinations were included.

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  • The advancement of deep learning in medical imaging has improved AI capabilities but has created challenges like the need for large training datasets and extensive labeling efforts.
  • Generative adversarial networks (GANs) offer innovative solutions by generating synthetic images for data augmentation and enhancing medical image processing tasks, which reduces reliance on labeled data.
  • This paper provides radiologists new to GAN technology with insights on various GAN architectures, training considerations, and practical applications, particularly in brain imaging, to encourage further research in the field.
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  • - The study presents a real-time classification system for alcoholic beverages utilizing low-cost gas sensors and machine learning, inspired by the superior olfactory capabilities of dogs.
  • - By leveraging data from 30 gas sensors, the system achieved an impressive classification accuracy of over 99% across different types of alcoholic beverages, showcasing the impact of effective data preprocessing and sensor quantity on performance.
  • - The results indicate that the electronic nose system developed performs similarly to commercial systems, confirming its potential for real-time classification of alcoholic beverages.
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Purpose: To investigate whether a difference exists in intereye glaucoma severity and progression in patients with asymmetric axial length.

Design: Long-term observational study.

Participants: Patients older than 20 years with a diagnosis of glaucoma at Seoul National University Hospital, Seoul, Korea, between 2010 and 2020.

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  • The text highlights the complexity of the tissue microenvironment (TiME) and the challenges in understanding its organization over time and space.
  • It discusses recent advancements in engineering and data science that enable detailed study of TiME, although many innovations remain isolated without integration.
  • The review offers a comprehensive overview of various technologies and their applications, aiming to enhance understanding of TiME's role in diseases and development, while also emphasizing the importance of collaboration in research efforts.
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Evaluating the dynamic interaction of microorganisms and mammalian cells is challenging due to the lack of suitable platforms for examining interspecies interactions in biologically relevant coculture conditions. In this work, we demonstrate the interaction between probiotic bacteria ( and ) and A498 human cancer cells , utilizing a hydrogel-based platform in a label-free manner by infrared spectroscopy. The strain recapitulated in the compartment system secretes polypeptide molecules such as nisin, which has been reported to trigger cell apoptosis.

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Mycobacterium tuberculosis can reside and persist in deep tissues; latent tuberculosis can evade immune detection and has a unique mechanism to convert it into active disease through reactivation. M. tuberculosis Rv1421 (MtRv1421) is a hypothetical protein that has been proposed to be involved in nucleotide binding-related metabolism in cell-growth and cell-division processes.

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Cross-sectional imaging plays a crucial role in the detection, diagnosis, staging, and resectability assessment of intra- and extrahepatic cholangiocarcinoma. Despite this vital function, there is a lack of standardized CT and MRI protocol recommendations for imaging cholangiocarcinoma, with substantial differences in image acquisition across institutions and vendor platforms. In this review, we present standardized strategies for the optimal imaging assessment of cholangiocarcinoma including contrast media considerations, patient preparation recommendations, optimal contrast timing, and representative CT and MRI protocols with individual sequence optimization recommendations.

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  • - The study aimed to understand how the shape and size of β-zone parapapillary atrophy (PPA) in glaucoma patients can predict disease progression using Optical Coherence Tomography (OCT) analysis over a mean follow-up of nearly 10 years.
  • - Researchers analyzed 210 patients with primary open-angle glaucoma and found that larger radial and angular extents of β-zone PPA were linked to faster progression of glaucoma, highlighting the importance of PPA characteristics.
  • - Among different shapes of β-zone PPA, the Solar-eclipse type 2 had the highest progression rate, indicating that both PPA morphology and size are crucial for predicting how glaucoma might worsen in patients.
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Bacteria-assisted chemotherapeutics have been highlighted as an alternative or supplementary approach to treating cancer. However, dynamic cancer-microbe studies at the level have remained a challenge to show the impact and effectiveness of microbial therapeutics due to the lack of relevant coculture models. Here, we demonstrate a hydrogel-based compartmentalized system for prodrug activation of a natural ingredient of licorice root, glycyrrhizin, by microbial β-glucuronidase (GUS).

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Purpose: To provide an updated analysis of the long-term outcomes of patients with acute primary angle closure (APAC) and to investigate the risk factors for visual field (VF) loss progression.

Study Design: Retrospective, clinical cohort study METHODS: One hundred and forty-six APAC patients with a minimum of 1-year follow-up were included. The presenting features and the treatment utilized were recorded.

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  • A study evaluated the effectiveness of no-touch radiofrequency ablation (NT-RFA) with twin cooled wet electrodes in patients with recurrent hepatocellular carcinoma (HCC) after prior treatments, involving 102 patients and 112 tumors.
  • The study found that 21.4% of cases needed to switch to conventional RFA, but overall treatment success was high at 99.1%, with no major complications reported.
  • Mid-term analyses showed low rates of local tumor progression (LTP), with significant predictive factors identified, including the number of prior treatments and certain patient health indicators.
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  • This systematic review and meta-analysis examined the effectiveness and safety of East Asian herbal medicine for treating iron deficiency anemia (IDA) in children and adolescents.
  • Researchers analyzed data from 28 randomized controlled trials, focusing on key outcomes such as blood hemoglobin levels, serum ferritin levels, and incidence of adverse events.
  • The results showed that herbal medicine significantly improved treatment outcomes compared to oral iron alone and had a lower occurrence of gastrointestinal side effects.
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  • Ultrasound (US) is commonly used for hepatocellular carcinoma (HCC) surveillance in high-risk patients, but its effectiveness in detecting early-stage HCC is limited.
  • A study compared biannual US with annual non-contrast abbreviated magnetic resonance imaging (NC-AMRI) over a 30-month period in patients with a high risk of HCC.
  • Results showed that NC-AMRI had a slightly higher sensitivity and significantly better diagnostic yield for HCC detection compared to US, suggesting alternating these methods every six months may provide the best surveillance strategy for high-risk patients.
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  • * Data was collected from over 6,500 patients who underwent esophagogastroduodenoscopy (EGD) and abdominal CT, revealing that higher visceral adipose tissue (VAT) correlated with increased RE risk and that fat reduction could improve disease severity.
  • * Findings suggest that targeting visceral obesity could be an effective strategy in treating reflux esophagitis, as reducing VAT was linked to better outcomes in patients.
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  • A lithium metal anode in rechargeable batteries needs uniform lithium plating on the copper current collector during charging; however, in practice, this plating can be uneven, leading to inefficiencies and lithium dendrite formation.
  • The study uses advanced calculations and experiments to analyze how lithium interacts with copper and its oxide (CuO), finding that while both materials attract lithium, the lithium does not spread well on the oxide.
  • This uneven interaction creates regions on the current collector that can cause long-term issues in battery performance, highlighting important factors that affect lithium plating efficiency in anode-free battery systems.
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Capillary-driven heat pipes are an effective thermal solution for compacting electronic cooling systems. We advance such a heat pipe thermal solution with ultralightweighting for mobile applications. In our advancement, the envelope that encapsulates the phase-change process of a working fluid is fabricated via electroless plating being ∼40 μm thick.

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  • The study investigates the effectiveness of four different international guidelines for diagnosing hepatocellular carcinoma (HCC) using gadoxetic acid-enhanced MRI in high-risk patients.
  • A total of 2,445 focal liver lesions were analyzed, with the Korean guideline (KLCA-NCC) showing the highest accuracy at 80%, while sensitivity was high for Eastern guidelines and specificity was strong for Western guidelines.
  • Results indicate significant differences in diagnostic performance among the guidelines, with diagnostic odds ratios helping to quantify their effectiveness in detecting HCC.
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This study aimed to explore the needs and wants of older adults in the context of movement-assistive clothing (MSC), with a focus on muscle strength and posture correction. A survey was conducted to understand the needs and wants of older adults, considering aspects of functions and designs, and to evaluate the comfort, safety, ease of use, usefulness, and intention of users to purchase and use products. A total of 408 individuals aged > 65 years participated in the study.

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  • The study focuses on glaucoma patients who have myopia, revealing that more severe myopia is linked to quicker loss of visual acuity and worsening of central visual field defects.
  • Conducted as a longitudinal observational study, it categorized patients into mild, moderate, and high myopia groups to compare their clinical progression over an average follow-up of 10.4 years.
  • Results indicated that as myopia severity increased, the rates of retinal nerve fiber layer thinning and visual field deterioration were faster, with high myopia showing a significantly greater risk of visual impairment.
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