Publications by authors named "Jeong Yeon Yoo"
We developed a design strategy focusing on pivotal secondary structural motifs-α-helix, β-strand, and β-turn-critical for PPI recognition, using a common core skeleton. The resulting peptide-inspired pyrimidodiazepine scaffolds were further subjected to comprehensive phenotypic screening to evaluate their efficacy. Our strategy offers a transformative approach to developing small-molecule PPI modulators with broad therapeutic potential.
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- Protein-protein interactions (PPIs) are crucial for many biological functions and diseases, making them important but challenging targets for drug development.
- Traditional drug discovery has focused on enzymes and receptors, which have smaller binding sites, leaving a gap in strategies to successfully target PPIs.
- To overcome these challenges, a new strategy called privileged substructure-based diversity-oriented synthesis (pDOS) was developed, incorporating pyrimidine-based compounds to create diverse chemical structures that can effectively interfere with PPIs, including inhibiting the interaction between human ACE2 and the SARS-CoV-2 spike protein.
A bioequivalence study of the ambroxol hydrochloride tablets was conducted. Twenty-four healthy male Korean volunteers received each medicine at the ambroxol hydrochloride dose of 30 mg in a 2 x 2 cross-over study. There was a 1-week washout period between the doses.
View Article and Find Full Text PDFA sensitive and selective liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed for the quantification of ambroxol in human plasma. Domperidone was used as internal standard, with plasma samples extracted using diethyl ether under basic condition. A centrifuged upper layer was then evaporated and reconstituted with 200 microl methanol.
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