Publications by authors named "Jeong Su Cho"

Article Synopsis
  • The study assessed the effectiveness of different sampling methods for next-generation sequencing (NGS) in lung cancer diagnostics, based on data from patients at Pusan National University Hospital.
  • Overall, NGS yielded a high success rate of 97.5% across 319 patients, with no significant differences in DNA sequencing success between surgical (98%) and nonsurgical (96.4%) methods.
  • However, surgical methods had a lower success rate for RNA sequencing (78%) compared to nonsurgical methods (92.3%), suggesting a need for improved protocols to mitigate RNA degradation during surgical sampling.
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Purpose: Invasive mucinous adenocarcinoma (IMA) of the lungs is a rare subtype of lung adenocarcinoma with a limited understanding of its prognosis, particularly in advanced stages. This study aimed to assess the prognosis of patients with advanced IMA by focusing on treatment modalities.

Methods: This single-center retrospective study evaluated 33 patients with IMAs diagnosed with advanced-stage disease or disease progression after curative treatment between 2011 and 2021.

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Purpose: The use of neoadjuvant anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (TKIs) has not been extensively explored. The current case report highlights the notable pathological complete response (pCR) achieved following neoadjuvant brigatinib therapy in a patient with stage IIIA ALK-positive non-small cell lung cancer (NSCLC).

Case Presentation: A 32-year-old male presented with incidental lung lesions, ultimately diagnosed as clinical stage T3N1M0, IIIA NSCLC with an gene rearrangement.

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Article Synopsis
  • Recent advances in treating resectable non-small cell lung cancer (NSCLC), particularly the ADAURA trial, highlight the effectiveness of osimertinib for patients at high risk of relapse, necessitating further studies to identify these specific subgroups.
  • A study analyzing data from 3,176 NSCLC patients concluded that 14.0% experienced late recurrence, with the EGFR-mutant subgroup being particularly studied for relapse factors.
  • Key factors influencing postoperative relapse in patients with EGFR mutations include age, pathologic N and TNM stages, pleural invasion status, and type of surgery, indicating that those with advanced conditions or specific surgical histories are at greater risk.
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Background: For patients with stage II and III non-small cell lung cancer (NSCLC), various multi-modality treatments are required. However, depending on the individual conditions of patients, there will be a significant difference in prognosis. Therefore, this study investigated the clinical impact of inadequate treatment (limited surgery and inadequate adjuvant therapy) in patients with NSCLC stage II or III using data from the Korean Association of Lung Cancer Registry (KALC-R) between 2014 and 2016.

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Background: Malignant pleural effusion affects many patients with advanced cancer. When chemotherapy or radiotherapy fails to relieve malignant pleural effusion and related symptoms, drainage and pleurodesis can help. Although surgical talc pleurodesis is the most widely used method, , which has been recently used in surgical or bedside procedures, has demonstrated significant results and is as effective as talc.

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mutational status in resected non-small cell lung cancer (NSCLC) in the Korean population is poorly understood. We explored (particularly V600E) mutational status among Korean patients with NSCLC. : This study included 378 patients with resected primary NSCLC who were enrolled from January 2015 to December 2017.

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Objectives: To compare the analgesic efficacies of erector spinae plane (ESP) block and thoracic epidural analgesia (TEA) in video-assisted thoracic surgery (VATS).

Methods: Sixty patients undergoing VATS received patient-controlled TEA with a basal rate of 3 ml/hour (h), a bolus of 3 ml (Group E), or ESP block with programmed intermittent bolus infusions of 15 mL/3 h and a bolus of 5 ml (Group ES) for 2 postoperative days. The primary outcome was to compare pain scores at rest 24 h postoperatively between the 2 groups.

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Background: Extracranial cerebrovascular diseases represent approximately 20% of ischemic stroke cases. Carotid endarterectomy (CEA) was the gold standard procedure for carotid artery stenosis treatment until the introduction of carotid artery stenting (CAS) in the 1980s. While there have been several multicenter randomized trials comparing CEA and CAS, a more efficacious procedure has not been conclusively distinguished.

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Article Synopsis
  • - The study explored the connection between sarcopenia (muscle loss) and physical function in healthy adults, highlighting the need for early detection methods, especially in younger populations.
  • - Involving 85 healthy male participants averaging 59.76 years, researchers used abdominal CT scans to categorize subjects into sarcopenia and non-sarcopenia groups based on muscle mass.
  • - Findings indicated that lower physical performance was linked to sarcopenia, and suggested that calf circumference could be a reliable measurement tool for diagnosing sarcopenia, offering better specificity compared to other methods like bioelectrical impedance analysis.
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: As the number of minimally invasive surgeries, including video-assisted thoracoscopic surgery, increases, small, deeply located lung nodules are difficult to visualize or palpate; therefore, localization is important. We studied the use of a mixture of indigo-carmine and lipiodol, coupled with a transbronchial approach-to achieve accurate localization and minimize patient discomfort and complications. : A total of 60 patients were enrolled from May 2019 to April 2022, and surgery was performed after the bronchoscopy procedure.

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: The estimation of lung function impairment after pulmonary lobectomy for primary non-small cell lung cancer (NSCLC) has been of great interest since the reduction of respiratory function might severely affect a patient's quality of life. The perioperative factors that may have an influence on widening the gap between the postoperative measured lung function and predicted postoperative lung function were our greatest concern. We aimed to analyze the perioperative patient factors that may influence postoperative lung function in patients undergoing pulmonary lobectomy.

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This cross-sectional study aimed to compare the accelerometer-assessed physical activity (PA) and sedentary behavior (SB) of adults with Prader-Willi syndrome (PWS) attending or not attending a small-scale community workshop (SSCW). A total of 18 adults with PWS were recruited in this study. Of these participants, 10 regularly attended an SSCW and 8 did not.

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Purpose: This study aimed to provide the clinical characteristics, prognostic factors, and 5-year relative survival rates of lung cancer diagnosed in 2015.

Materials And Methods: The demographic risk factors of lung cancer were calculated using the KALC-R (Korean Association of Lung Cancer Registry) cohort in 2015, with survival follow-up until December 31, 2020. The 5-year relative survival rates were estimated using Ederer II methods, and the general population data used the death rate adjusted for sex and age published by the Korea Statistical Information Service from 2015 to 2020.

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Background: No consensus exists regarding whether volatile anesthetics are superior to intravenous anesthetics for reducing postoperative pulmonary complications (PPCs) in patients undergoing general anesthesia for surgery. Studies of this issue focused on anatomic pulmonary resection are lacking. This study compared the effects of total intravenous anesthesia (TIVA) versus volatile anesthesia on PPCs after anatomic pulmonary resection in patients with lung cancer.

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Purpose: Information and communication technology (ICT)-based training devices for older adults' care related to dementia are being developed to enhance older adults' cognitive functions. Older adults who require bicycle training devices can improve muscle strength and balance of lower limbs by continuously contracting and relaxing lower-limb muscles and improving cognitive function to prevent dementia. This study was conducted to investigate the effects of an ICT-based multicomponent program on body composition and cognitive function in older adults.

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Here, we report the rare case of a 13-year-old girl with a congenital diaphragmatic hernia (also known as Bochdalek hernia), which was revealed to be an extralobar pulmonary sequestration that was treated using laparoscopic and video-assisted thoracic surgery sequestrectomy and repair of the diaphragm defect after detection of a supradiaphragmatic mass connected with the retroperitoneum. The patient showed no postoperative complications at a 1-month follow-up examination.

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Bronchopulmonary sequestration (BPS) is a rare congenital abnormality of the lower airway, generally characterized by blood supply received from the systemic circulation. We present a rare case of a 19-year-old man with incidentally detected BPS supplied by a branch of a pulmonary artery, rather than a systemic artery. Computed tomography showed a sequestered segment supplied by a branch of the left pulmonary artery and containing an ectopic bronchus.

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Inflammatory myofibroblastic tumor is a rare benign lesion that accounts for 0.04-1% of all lung tumors and usually appears as a solitary pulmonary nodule or mass. Here, we report the case of an endobronchial inflammatory myofibroblastic tumor in a 21-year-old man with a focus on the imaging findings and a review of previous literature.

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Background: Postoperative chylothorax may be caused by iatrogenic injury of the collateral lymphatic ducts after thoracic surgery. Although traditional treatment could be considered in most cases, resolution may be slow. Radiological interventions have recently been developed to manage postoperative chylothorax.

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Article Synopsis
  • * It involved 146 patients who had lobectomies between 2008 and 2012, evaluating histopathologic factors and TIL levels, finding significant correlations with other factors such as histologic grade and necrosis.
  • * High levels of TILs were linked to improved progression-free (p = 0.011) and overall survival (p = 0.049), indicating that TILs serve as a good independent prognostic factor in lung adenocarcinoma. *
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