Accuracy of macroscopic intraoperative diagnosis of serosal invasion and risk of over- and underestimation in gastric carcinoma.

Background: Accurate intraoperative diagnosis of serosal invasion is a prerequisite for proper application of invasive procedures, such as intraperitoneal chemohyperthermia, for serosa positive gastric carcinomas.

Methods: We reviewed the prospectively constructed data of 1,265 gastric cancer patients who underwent surgery between 2007 and 2009. Accuracies of macroscopic diagnoses of serosal invasion were determined by comparing with pathological findings.

New paradigm of multi-chip white LEDs: combination of an InGaN blue LED and full down-converted phosphor-converted LEDs.

This study introduces innovative multi-chip white LED systems that combine an InGaN blue LED and green/red or green/amber/red full down-converted, phosphor-conversion LEDs (pc-LEDs). Efficient green, amber, and red full down-converted pc-LEDs were fabricated by simply capping a long-wave pass filter (LWPF) on top of LED packing associated with each corresponding powder phosphor. The principal advantage of this type of color-mixing approach in newly developed multi-chip white LEDs based on colored pc-LEDs is thought to be dynamic control of the chromaticity and better light quality.

Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer.

Background: Elevated neutrophil to lymphocyte ratio (N/L ratio) has been shown to be a prognostic indicator in various cancers. We aimed to investigate the prognostic significance of the preoperative N/L ratio in late stage gastric cancer.

Methods: From April 2004 to August 2007, 293 patients who had undergone gastrectomy with curative intent for the AJCC/UICC TNM Stage III or IV gastric cancer were included.

Impaired expansion of trophoblast spheroids cocultured with endometrial cells overexpressing cellular retinoic acid-binding protein 2.

We previously showed that the cellular retinoic acid-binding protein 2 (CRABP2) gene was up-regulated during the implantation window period in the endometrium of patients with unexplained recurrent spontaneous abortion. Here, we report that trophoblast spheroids cocultured with a human endometrial cell line stably overexpressing CRABP2 are defective in expansion and exhibit apoptosis, suggesting that the altered expression level of endometrial CRABP2 is involved in abnormal endometrium-trophoblast interaction, which leads to implantation failure.

Association of comorbidities with overall survival in myelodysplastic syndrome: development of a prognostic model.

Purpose: Patients with cancer often experience comorbidities that may affect their prognosis and outcome. The objective of this study was to determine the effect of comorbidities on the survival of patients with myelodysplastic syndrome (MDS).

Patients And Methods: We conducted a retrospective cohort study of 600 consecutive patients with MDS who presented to MD Anderson Cancer Center from January 2002 to December 2004.

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.

Oocyte maturation, fertilization, and early embryonic development occur in the absence of gene transcription. Therefore, it is critical to understand at a global level the post-transcriptional events that are driving these transitions. Here we used a systems approach by combining polysome mRNA profiling and bioinformatics to identify RNA-binding motifs in mRNAs that either enter or exit the polysome pool during mouse oocyte maturation.

Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes.

Waves of cyclin synthesis and degradation regulate the activity of Cdc2 protein kinase during the cell cycle. Cdc2 inactivation by Wee1B-mediated phosphorylation is necessary for arrest of the oocyte at G2-prophase, but it is unclear whether this regulation functions later during the metaphase-to-anaphase transition. We show that reactivation of a Wee1B pathway triggers the decrease in Cdc2 activity during egg activation.

The realization of a whole palette of colors in a green gap by monochromatic phosphor-converted light-emitting diodes.

A variety of efficient green, yellow, and amber monochromatic phosphor-converted light-emitting diodes (pc-LEDs) were fabricated by simply capping a long-wave pass filter (LWPF) on top of LED packing associated with each corresponding powder phosphor. In this paper, the luminous efficacy and color purity of two green, three yellow, and two amber pc-LEDs were reviewed by comparing the optical properties and current/temperature stability of each LWPF-capped pc-LED. The simple combination of LWPFs and phosphor materials in the pc-LEDs provide a simple means of addressing the low luminous efficacy problem of III-V monochromatic semiconductor LEDs in the various colors of the wavelength range between green and amber (known as the "green gap").

Predisposing factors and management of postoperative bleeding after radical gastrectomy for gastric carcinoma.

Purpose: To promote proper management of postoperative bleeding, we investigated the clinical manifestations, predisposing factors, diagnostic approaches, and treatments of bleeding complications after gastric cancer surgery.

Methods: Using a prospectively constructed database, we reviewed retrospectively 39 patients who suffered bleeding complications from among a total 1027 patients who underwent surgery for gastric cancer between 2004 and 2008.

Results: Operating time (hazard ratio [HR] 1.

An unusual presentation of a severely calcified parasitic leiomyoma in a postmenopausal woman.

We report the case of a calcified parasitic leiomyoma in a 51-year-old postmenopausal woman with lower abdominal discomfort. She had no history of surgery. Workup confirmed a calcified leiomyoma.

Observation and simulation of all angular magnetoresistance oscillation effects in the quasi-one-dimensional organic conductor (DMET)(2)I(3).

Measurements and calculations of magnetotransport in the organic conductor (DMET)(2)I(3) detect and simulate all angular magnetoresistance oscillations known for quasi-one-dimensional conductors. By employing the actual triclinic crystal structure in the calculations, these results address the putative vanishing of the primary magnetoresistance phenomenon, the Lebed magic angle effect, for orientations in which it was expected to be strongest. They also show a common origin for Lebed and the so-called Lee-Naughton oscillations and confirm the generalized nature of angular effects in such systems.

Evaluation of in vitro spermatogenesis using poly(D,L-lactic-co-glycolic acid) (PLGA)-based macroporous biodegradable scaffolds.

Successful in vitro differentiation of spermatogenic cells into spermatids appears to offer extremely attractive potential for the treatment of impaired spermatogenesis and male infertility. Experimental evidence indicates that biocompatible polymers may improve in vitro reconstitution and regeneration of tissues of various origins. Here, we fabricated highly porous biodegradable poly(D,L-lactic-co-glycolic acid) or PLGA co-polymer scaffolds by combining the gas-foaming and salt-leaching methods, using ammonium bicarbonate as a porogen, which allowed us to generate polymer scaffolds with a high density of interconnected pores of 400-500 µm in average diameter, concomitant with a high malleability to mould a wide range of temporal tissue scaffolds requiring a specific shape and geometry.

Full down-conversion of amber-emitting phosphor-converted light-emitting diodes with powder phosphors and a long-wave pass filter.

This paper reports the possibility of a facile optical structure to realize a highly efficient monochromatic amber-emitting light-emitting diode (LED) using a powder-based phosphor-converted LED combined with a long-wave pass filter (LWPF). The capping of a blue-reflecting and amber-passing LWPF enhances both the amber emission from the silicate amber phosphor layer and the color purity due to the blocking and recycling of the pumping blue light from the InGaN LED. The enhancement of the luminous efficacy of the amber pc-LED with a LWPF (phosphor concentration 20 wt%, 39.

Enhancement of bacteriophage λ stability using a λQ-S- mutant in the continuous culture of Escherichia coli.

In this study, we used a bacteriophage λQ⁻S⁻ mutant that increased the stability of recombinant Escherichia coli during continuous culture. The operation was conducted in two stages: the first stage was carried out to promote cell growth, and the second stage was performed for product formation. The productivity of recombinant proteins depends on the substrate concentration of the fresh medium supplied to the second stage (S₃) and dilution rate of the second stage (D₂).

Alterations in differentially expressed genes in the head of Oryzias latipes following benzo[a]pyrene exposure.

Differentially expressed genes (DEGs) in the head of medaka (Oryzias latipes) were investigated to assess the biological effects of benzo[a]pyrene (BaP) on genomic alterations. Eight and ten DEGs were identified in response to short (48 h) and long-term (15 days) exposure to BaP (25 microg/L), respectively, using annealing control primer-based polymerase chain reaction. Among the DEGs, matrilin 1 and prothrombin were commonly detected, suggesting that BaP exposure can alter the expression of genes associated with the formation of extracellular matrix and blood coagulation in the head of medaka.

The effect of low molecular weight heparin thromboprophylaxis on bleeding complications after gastric cancer surgery.

Background: Low molecular weight heparin (LMWH) has been widely used to prevent venous thromboembolism in cancer surgical patients. However, relatively few studies have examined the safety aspects related to the use of LMWH after abdominal cancer surgery. This study was designed to investigate the relationship between bleeding complications and LMWH thromboprophylaxis after gastric cancer surgery.

Highly efficient phosphor-converted white organic light-emitting diodes with moderate microcavity and light-recycling filters.

We demonstrate the combined effects of a microcavity structure and light-recycling filters (LRFs) on the forward electrical efficiency of phosphor-converted white organic light-emitting diodes (pc-WOLEDs). The introduction of a single pair of low- and high-index layers (SiO(2)/TiO(2)) improves the blue emission from blue OLED and the insertion of blue-passing and yellow-reflecting LRFs enhances the forward yellow emission from the YAG:Ce(3+) phosphors layers. The enhancement of the luminous efficacy of the forward white emission is 1.

Expression analysis of the Adam21 gene in mouse testis.

A number of members belonging to a disintegrin and metalloprotease (ADAM) family of cell surface proteins, including ADAM21, are expressed specifically or predominantly in the mammalian testis. Here, we investigated the transcriptional characteristics of the Adam21 gene. We found that Adam21 produces two types of transcripts with different developmental stages and cellular localizations.

Effect of age on surgical outcomes of extended gastrectomy with D2 lymph node dissection in gastric carcinoma: prospective cohort study.

Background And Purpose: As a life expectancy increases, the proportion of aged patients diagnosed with gastric cancer has increased over the past decades, but the optimal surgical approach to these patients remains a dilemma because of the presumed risk associated with extended surgery.

Methods: A total of 383 consecutive patients who underwent gastrectomy with D2 lymph node dissection in 2008 and 2009 were enrolled onto this study. Patients were divided into two age groups (<70 vs.

Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption.

After a long period of quiescence at dictyate prophase I, termed the germinal vesicle (GV) stage, mammalian oocytes reenter meiosis by activating the Cdc2-cyclin B complex (maturation-promoting factor [MPF]). The activity of MPF is regulated by Wee1/Myt1 kinases and Cdc25 phosphatases. In this study, we demonstrate that the sequestration of components that regulate MPF activity in distinct subcellular compartments is essential for their function during meiosis.

ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane.

During epididymal transit, mammalian sperm acquire selected proteins secreted by the epididymis. We previously showed that a disintegrin and metalloprotease (ADAM) 7 is expressed specifically in the epididymis and transferred to the sperm surface during epididymal transit. Here, we show that mouse ADAM7 secreted to the epididymal lumen is associated with membranous vesicles known as epididymosomes.

Accuracy of surgical diagnosis in detecting early gastric cancer and lymph node metastasis and its role in determining limited surgery.

Background: The aim of this study was to evaluate the accuracy of surgical diagnosis of early gastric cancer (EGC) and lymph node metastasis, and elucidate its role in determining limited surgery for EGC.

Study Design: We reviewed 369 patients undergoing gastrectomy for primary gastric carcinoma. Surgical diagnosis was evaluated by determining its sensitivity, specificity, and accuracy, and was compared with preoperative examinations.

Expression and regulation of ribulose 1,5-bisphosphate carboxylase/oxygenase genes in Mycobacterium sp. strain JC1 DSM 3803.

Ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) is the key enzyme of the Calvin reductive pentose phosphate cycle. Two sets of structural genes (cbbLS-1 and -2) for form I RubisCO have been previously identified in the Mycobacterium sp. strain JC1, which is able to grow on carbon monoxide (CO) or methanol as sole sources of carbon and energy.

Appropriate selection of patients for combined organ resection in cases of gastric carcinoma invading adjacent organs.

Background And Objectives: Proper patient selection for multi-organ resection in T4 gastric carcinoma remains controversial. Our aim was to investigate which patients might benefit from multi-organ resection.

Methods: Among 1,775 consecutive patients receiving gastric cancer surgery, 71 had adjacent organ invasion.

Enhanced forward efficiency of Y3Al5O12:Ce3+ phosphor from white light-emitting diodes using blue-pass yellow-reflection filter.

This paper reports a simple approach for the design of blue-excitation-light passing and phosphor-yellow-emission-light reflecting dielectric multilayers to recycle the backward emission of Y(3)Al(5)O(12):Ce(3+) (YAG:Ce) yellow phosphors on top of a blue InGaN light-emitting diode (LED) cup. The insertion of modified quarter-wave films of alternate high- and low-refractive index dielectric films (TiO(2)/SiO(2)) into the interface between a YAG:Ce phosphor layer and glass substrate resulted in 1.64 and 1.