Publications by authors named "Jeong Kuen Song"
Article Synopsis
- Neurofibrillary tangles (NFTs), linked to Alzheimer's disease (AD) neurodegeneration, consist of hyperphosphorylated tau proteins, particularly affecting memory in the hippocampus.* -
- The study investigated the effects of AL04, a new protein treatment, on lowering hyperphosphorylated tau in a specific mouse model with human tau mutation, revealing significant decreases in tau levels and changes in autophagy-related proteins.* -
- Findings suggest that AL04 could serve as a potential preventive and therapeutic agent for AD by promoting tau degradation and regulating relevant protein pathways.*
Article Synopsis
- - Alzheimer's disease (AD) is marked by amyloid beta plaques and neurofibrillary tangles, and drug development is hindered by the blood-brain barrier (BBB) preventing effective drug delivery.
- - Researchers created a fusion protein called AL04, incorporating a carrier (human serum albumin) and a therapeutic agent (Cystatin C) to enhance drug stability and BBB permeability.
- - Experiments with AL04 showed reduced neurotoxicity in cell models and significantly lowered amyloid beta plaques in an AD mouse model, indicating its potential as a treatment for Alzheimer's.
The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Although individual components are known, the relationships among them remain unresolved. We now use FRET measurements of pathway activity, analysis of protein localization and genetic epistasis to dissect the structure of this network in Drosophila We find that the adaptor protein Disabled stimulates Abl kinase activity.
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