Comparison of epidermal/dermal damage between the long-pulsed 1064 nm Nd:YAG and 755 nm alexandrite lasers under relatively high fluence conditions: quantitative and histological assessments.

Objective: The purpose of this study was to compare degrees of epidermal/dermal tissue damage quantitatively and histologically after laser irradiation, to find ideal treatment conditions with relatively high fluence for skin rejuvenation.

Background Data: A number of recent studies have evaluated the clinical efficacy and safety of therapeutic lasers under relatively low fluence conditions.

Methods: We transmitted the long-pulsed 1064 nm Nd:YAG and 755 nm Alexandrite lasers into pig skin according to different fluences and spot diameters, and estimated epidermal/dermal temperatures.

The effects of 1064 nm Nd:YAG laser irradiation under the different treatment conditions for skin rejuvenation: quantitative and histologic analyses.

Objective: The aim of this study was to estimate heat distributions and evaluate degrees of tissue damages histologically after transmitting therapeutic lasers to find optimum ranges for skin rejuvenation.

Background Data: To treat skin aging, many researchers attempted to evaluate treatment effects for the different approaches. The noninvasive skin rejuvenation method was mostly employed to optimize the therapeutic effects by quantifying the laser conditions.