Publications by authors named "Jeong E Lee"

Background: The incidence of sepsis with identified fungal pathogens is increasing and is associated with higher morbidity and mortality. Co-infection with fungal infections in COVID-19 patients is attracting clinical attention. This study examines the epidemiology, risk factors, and outcomes among sepsis patients with identified fungal pathogens.

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Purpose: Breast cancer gene () mutation is a well-known risk factor for breast cancer, and clinical interest in prophylactic mastectomy has increased in recent years. We investigated patients who were mutation carriers and underwent contralateral risk-reducing mastectomy (RRM), focusing on the incidence of occult malignancy after contralateral RRM.

Methods: Prospectively collected data of patients with breast cancer treated at a single institution were retrospectively reviewed.

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Objectives: This study compared the efficacy of cefazolin in a mouse pneumonia model caused by a methicillin-susceptible Staphylococcus aureus (MSSA) strain with cefazolin inoculum effect (CIE) and its blaZ-eliminated derivative.

Methods: An isogenic blaZ gene-eliminated strain was derived from type A blaZ-positive MSSA blood isolates exhibiting CIE: PNIDSA230 (parental strain, CIE+) and PNIDSA230c (blaZ-eliminated strain, CIE-). Mice were inoculated with 2 × 10⁶ to 2 × 10⁷ cfu of MSSA via endotracheal tubes and treated with intraperitoneal cefazolin or oxacillin 5 h post-inoculation.

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Background/objectives: Isoflavones are estrogen-like compounds found in plants and their health effects remain equivocal. We investigated dietary isoflavone intake and its associated factors in Korean breast cancer survivors, with a comparison to cancer-free women.

Subjects/methods: The usual dietary intake of breast cancer survivors (n = 981, mean age 52 yrs) in 9 hospitals between 2012 and 2019 was assessed using 3-day food records or food frequency questionnaires (FFQs).

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The kidney, the most frequently transplanted organ, represents the optimal treatment for end-stage renal disease. Transplanted kidneys are highly vulnerable to perioperative injuries such as hypotension and hypovolemia, which can be influenced by perioperative fluid management. Postoperatively, delayed graft function increases the risk of graft failure.

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Incidentally detected gallbladder polyps (GBPs) and gallbladder wall thickening (GBWT) are frequently encountered in clinical practice. However, characterizing GBPs and GBWT in asymptomatic patients can be challenging and may result in overtreatment, including unnecessary follow-ups or surgeries. The Korean Society of Abdominal Radiology (KSAR) Clinical Practice Guideline Committee has developed expert recommendations that focus on standardized imaging interpretation and follow-up strategies for both GBPs and GBWT, with support from the Korean Society of Radiology and KSAR.

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Background: This study aimed to compare the response to growth hormone (GH) therapy according to the presence of GH deficiency (GHD) in short-stature children born small for gestational age (SGA) in Korea and to present appropriate GH dose criteria.

Methods: We evaluated 27 children born SGA with short stature and GHD (GHD group) and 23 without GHD (non-GHD group) registered in the LG Growth Study. Growth responses and changes in GH dose over a 2-year GH therapy period were compared, and the factors affecting growth response were investigated.

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Background: Interleukin-6 (IL-6) plays a central role in sepsis-induced cytokine storm involving immune hyperactivation and early neutrophil activation. Programmed death protein-1 (PD-1) is associated with sepsis-induced immunosuppression and lymphocyte apoptosis. However, the effects of simultaneous blockade of IL-6 and PD-1 in a murine sepsis model are not well understood.

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Sushi domain-containing protein 2 (SUSD2), a transmembrane protein containing a sushi motif, has been reported to have tumor-promoting functions in various types of cancer, including breast cancer. However, the regulatory mechanism of SUSD2 and its function in HER2-positive (HER2+) breast cancer have not been fully identified as yet. In this study, we explored the potential of targeting SUSD2 to overcome trastuzumab (TRZ) resistance in HER2+ breast cancer.

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Introduction: The provision of treatment for epidermal growth factor receptor (EGFR)-mutated nonsmall cell lung cancer (NSCLC) patients has increased in Korea. However, multicenter studies on the clinicopathologic dataset and treatment outcomes, using a large-scale dataset, have not been conducted. The current study is a prospective and retrospective multicenter observational cohort study that registers all stages of EGFR-mutated NSCLC patients.

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Purpose: This study aims to identify factors predicting mortality, including nutritional status, in patients with acute heart failure (AHF) admitted to the cardiac intensive care unit and to explore the implications of accurate early nutritional assessment.

Methods: This retrospective cohort study performed a secondary analysis of data from 357 patients admitted to a tertiary hospital in Seoul, Korea, from 2019 to 2022. The target patients were classified into high-risk and low-risk groups through the Nurses' nutritional assessment (NNA) using three questions and into normal, mild, moderate, and severe risk groups using the Nutritional Risk Index (NRI) including serum albumin.

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The spleen is occasionally referred to as the 'forgotten organ' because splenic lesions are less common and encountered rarely compared to pathologies of other abdominal solid organs. Therefore, although well-demonstrated using various abdominal imaging modalities, radiologists tend to be less familiar with splenic diseases, making interpretation challenging. This study aimed to review common and uncommon splenic diseases and illustrate the multimodal imaging (including ultrasonography, CT, MRI, and PET/CT) features of these lesions in correlation with their histopathology.

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Article Synopsis
  • Plasmids with wild-type and mutant type A genes were created and introduced into a bacterial strain called RN4220, resulting in four different strains: WT-blaZ, M226-blaZ, M229-blaZ, and MB-blaZ.
  • The study found that the minimum inhibitory concentration (MIC) of cefazolin was significantly lower in the strains with mutations at codon 226 (MB-blaZ and M226-blaZ) compared to the wild-type strain (WT-blaZ).
  • This indicates that a mutation at codon 226 affects the bacteria's resistance to cefazolin, while the mutation at codon 229 did not have the same effect.
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Purpose: This study aimed to analyze the incidence of cancer therapy-related cardiovascular toxicity (CTRCVT) and identify the radiation dosimetric and clinical risk factors for these events in patients with human epidermal growth factor receptor 2-positive breast cancer.

Methods And Materials: Data from 1378 patients who were treated with curative surgery and adjuvant trastuzumab for breast cancer were retrospectively analyzed. A total of 959 patients underwent postoperative radiation therapy (RT), whereas 419 patients were managed without RT (no-RT).

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Background: Neoadjuvant chemotherapy (NACT) for early-stage breast cancer is associated with an increased risk of locoregional recurrence (LRR). We investigated whether the risk of LRR after NACT varies across tumor subtypes.

Methods: We retrospectively reviewed the medical records of women who underwent breast-conserving surgery for breast cancer at three institutions between January 1, 2004, and December 31, 2018.

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Article Synopsis
  • Young patients under 45 with ER-positive, ERBB2-negative breast cancer experience poor outcomes, with a focus on understanding factors that lead to late recurrence.
  • This study aimed to see if age affects the chances of late distant recurrence (DR) in patients who had no previous metastasis within 5 years post-surgery.
  • Out of 2772 patients analyzed, those aged 21-35 exhibited worse tumor grades and higher chemotherapy usage compared to older groups, indicating they may have a higher risk of late DR.
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Objective: To compare the image quality and lesion conspicuity of conventional vs deep learning (DL)-based reconstructed three-dimensional T1-weighted images in gadoxetic acid-enhanced liver magnetic resonance imaging (MRI).

Methods: This prospective study (NCT05182099) enrolled participants scheduled for gadoxetic acid-enhanced liver MRI due to suspected focal liver lesions (FLLs) who provided signed informed consent. A liver MRI was conducted using a 3-T scanner.

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  • The study investigated the effectiveness of patient-performed rapid antigen tests (RATs) in detecting COVID-19 variants Delta and Omicron during the pandemic, particularly in self-testing scenarios in Korea.
  • Researchers conducted a multicenter clinical study involving participants without prior diagnostic experience and compared RAT results with the more accurate reverse transcriptase-polymerase chain reaction (RT-PCR) testing.
  • Results showed that RATs were better at detecting the Omicron variant, while their performance for Delta was lower, especially among those who were only partially vaccinated, highlighting the need for careful use of these tests in different vaccination contexts.
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Background: Limited information is available on the clinical course and treatment outcomes of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection in Korea.

Materials And Methods: A retrospective case series was conducted of patients with HIV-HCV coinfection who received interferon (IFN)-based or direct-acting antiviral (DAA) treatment for HCV at a tertiary care hospital between 2000 and 2023. Early virological response (EVR) was defined as a 2-log reduction in HCV RNA levels or undetectable HCV RNA levels at treatment week 12.

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Purpose: This study aimed to evaluate the clinical outcomes and prognostic implications of regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NAC) in patients with residual triple-negative breast cancer (TNBC).

Materials And Methods: We analyzed 152 patients with residual TNBC who underwent breast-conserving surgery after NAC between December 2008 and December 2017. Most patients (n = 133; 87.

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Article Synopsis
  • - The study investigates how to predict whether suspicious calcifications in breast cancer patients post-neoadjuvant chemotherapy contain residual cancer, aiming to help surgeons choose the right surgical methods using a prediction model based on mammography and MRI results.
  • - Researchers analyzed data from 280 women and found that molecular subtype and high Ki-67 levels were significant factors in determining whether the calcifications were cancerous (ypCalc_ca) or not (ypCalc_0), leading to a predictive model with a strong accuracy in validation tests.
  • - The findings suggest that less invasive surgical options might be appropriate for specific cancer types, particularly in patients with certain hormone receptor and HER2 statuses alongside high Ki-67 levels.
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The influence of global climate change on temperature-related health outcomes among vulnerable populations, particularly young children, is underexplored. Using a case time series design, we analysed 647,000 hospital admissions of children aged under five years old in New Zealand, born between 2000 and 2019. We explored the relationship between daily maximum temperatures and hospital admissions across 2139 statistical areas.

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  • Classic Kaposi's sarcoma (CKS) is a rare cancer with various symptoms and no standard treatment, but radiotherapy (RT) has shown promise in treating skin lesions associated with the disease.
  • A study analyzed 69 lesions in 16 patients treated with RT from April 2012 to January 2024, finding a 100% overall response rate, with the majority achieving complete response (CR).
  • Despite some patients experiencing recurrence of lesions, all responded well to RT, indicating its effectiveness, although further research is necessary to optimize treatment protocols.
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Methyltransferase-like (METTL)18 has histidine methyltransferase activity on the RPL3 protein and is involved in ribosome biosynthesis and translation elongations. Several studies have reported that actin polymerization serves as a Src regulator, and HSP90 is involved in forming polymerized actin bundles. To understand the role of METTL18 in breast cancer and to demonstrate the importance of METTL18 in HER-2 negative breast cancer metastasis, we used biochemical, molecular biological, and immunological approaches (breast tumor cell lines), (tumor xenograft model), and in samples of human breast tumors.

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