Publications by authors named "Jeon Seong"
Background: Treatment for metastatic renal cell carcinoma (mRCC) has shifted from tyrosine kinase inhibitor (TKI) therapy to immune checkpoint inhibitor (ICI)-based therapy, improving outcomes but with variable individual responses. This study investigated the prognostic implications of pretreatment low skeletal muscle mass (LSMM) and myosteatosis in patients with mRCC undergoing first-line ICI-based therapies, comparing outcomes between PD-1 inhibitor + CTLA-4 inhibitor and PD-1 inhibitor + TKI, incorporating single-cell RNA sequencing.
Methods: A retrospective analysis was performed on 90 patients with mRCC treated with ICI-based therapies between November 2019 and March 2023.
Purpose: To assess the effectiveness of the prostate health index (PHI) in patients with no index lesions on multiparametric magnetic resonance imaging (mpMRI) or with negative findings on past prostate biopsy if there was an index lesion on mpMRI.
Materials And Methods: Patients without an index lesion on MRI or with a negative result on combined biopsy for index lesions were assessed. Patients who underwent transperineal mapping biopsy among those suspected of having prostate cancer (PCa) due to persistently elevated prostate-specific antigen (PSA) levels were analyzed.
Background And Aim: The impact of different anti-thrombotic agents on patients with suspected small bowel bleeding (SSBB) who underwent balloon-assisted enteroscopy (DAE) is unclear. We aimed to examine the clinical effects and predictive factors of DAE based on the thromboembolic agents used.
Methods: We enrolled 399 patients with SSBB from a web-based DAE registry across 30 medical centers in South Korea.
Article Synopsis
- - This study aimed to determine if tegoprazan is as effective as lansoprazole in healing erosive esophagitis (EE) within four weeks, with a specific focus on rapid mucosal healing and symptom relief by week two.
- - In a randomized trial of 218 patients, results showed that tegoprazan had significantly higher healing rates compared to lansoprazole at both two weeks (88.4% vs. 82.6%) and four weeks (95.2% vs. 86.2%).
- - The findings suggest that tegoprazan is superior to lansoprazole for treating EE, but more research is needed to fully understand its advantages, especially for severe cases
Endoscopic vacuum therapy (EVT) has emerged as a transformative approach for managing gastrointestinal (GI) transmural defects, offering a less invasive and more promising alternative to surgery. Initially developed to address anastomotic leaks after rectal surgery, the application of EVT has expanded to include other locations within the GI tract. This review investigated the principles, indications, procedures, outcomes, challenges, and future perspectives of EVT for the management of GI transmural defects.
View Article and Find Full Text PDFObjective: To analyze the outcomes of transperineal template-guided mapping biopsy (TTMB) in biopsy-naïve men with multiparametric magnetic resonance imaging (mpMRI) results of Prostate Imaging-Reporting and Data System (PI-RADS) 1-2.
Patients And Methods: We retrospectively reviewed TTMB outcomes in biopsy naïve patients with PI-RADS 1-2 at a single center from August 2018 to May 2023. The patients' clinicopathologic data were reviewed, clinically significant prostate cancer (csPCa) detection rates were identified.
Background And Aims: Polypectomy is a procedure associated with a high risk of bleeding. Guidelines recommend uninterrupted aspirin use during polypectomy, whereas cessation of clopidogrel 5 to 7 days before polypectomy is recommended. The cold snare resection (CSR) technique, with or without submucosal injection, is considered safer than conventional polypectomy using electrocoagulation for postpolypectomy bleeding.
View Article and Find Full Text PDFPurpose: This study aims to explore the relationship between soy food consumption and gastric cancer (GC) risk, accounting for infection status.
Materials And Methods: We analyzed data from patients with GC and healthy individuals prospectively enrolled by 6 hospitals between 2016 and 2018. Dietary intake was evaluated using questionnaires that categorized seven dietary habits and 19 food groups.
Background: This study investigated changes in students' perceptions related to research following a student-engaged medical research curriculum.
Methods: Three surveys were administered to 112 medical students to examine the changes in their perceptions of the need for research competence, research interest, and research self-efficacy after each Medical Research Practice course.
Results: The results revealed a decline in the perception of the need for research competence and research interest after Medical Research Practice 2, with a subsequent increase after Medical Research Practice 3.
Background/aims: Fecal microbiota transplantation (FMT) is a promising therapy for inducing and maintaining remission in patients with ulcerative colitis (UC). However, FMT has not been approved for UC treatment in Korea. Our study aimed to investigate patient perceptions of FMT under the national medical policy.
View Article and Find Full Text PDFThis study aimed to assess the prognostic role of body mass index (BMI) in patients with metastatic renal cell carcinoma (mRCC) treated with first-line immune checkpoint inhibitor (ICI)-based therapy. We searched for relevant studies in the MEDLINE, Embase, and Cochrane Library databases. The initial search yielded 599 records, of which seven articles (2,517 patients) were selected for analysis.
View Article and Find Full Text PDFPurpose: We investigated the relationship between body mass index (BMI), radiological body composition, and survival outcomes in patients with metastatic renal cell carcinoma (mRCC) underwent first-line immune checkpoint inhibitor (ICI)-based therapy.
Methods: Analyzing data from 102 patients treated between November 2019 and March 2023, pre-treatment computed tomography (CT) scans assessed fat and muscle areas. BMI and body composition indices were examined, including skeletal muscle index, subcutaneous fat index (SFI), visceral fat index, and total fat index.
Background: Xerostomia is a pathological condition characterized by decreased salivation due to salivary gland dysfunction and is frequently attributed to irreversible damage as a side effect of radiation therapy. Stem cell-derived organoid therapy has garnered attention as a promising avenue for resolving this issue. However, Matrigel, a hydrogel commonly used in organoid culture, is considered inappropriate for clinical use due to its undefined composition and immunogenicity.
View Article and Find Full Text PDFThe Search for an Ideal Definitive Treatment of Sinonasal Squamous Cell Carcinoma With Orbit Invasion.
Clin Exp Otorhinolaryngol
August 2024
Objectives: Sinonasal squamous cell carcinoma (SqCC) often invades the orbit. The treatment approach for sinonasal cancer that has spread to the orbit varies across medical centers and depends on the extent of the invasion. The decision to preserve the orbit in the treatment strategy is made on a case-by-case basis and.
View Article and Find Full Text PDFArticle Synopsis
- This text refers to a correction made for an article labeled e22 in volume 21, identified by the PubMed ID 34277112.
- The correction is meant to address errors or updates related to the original article.
- It's important for maintaining the accuracy and reliability of published research.
Article Synopsis
- - This study investigated the effects of combining radiation therapy (RT) and androgen deprivation therapy (ADT) in treating prostate cancer patients with suspected metastatic lymph nodes, analyzing records of 60 patients.
- - Results showed that after a median follow-up of 5.47 years, the treatment had a low biochemical failure rate (19.1%) and high overall survival rate (89.0%), with most adverse effects being mild.
- - The findings suggest that this combined treatment approach is effective and has manageable side effects, and may be suitable for patients with certain types of lymph node metastases.
Article Synopsis
- * Recent studies show that ESM can significantly reduce joint pain and slow cartilage damage in animal models of OA when taken before and after inducing the condition.
- * ESM appears to work by inhibiting inflammatory markers and enzymes that contribute to cartilage degradation, especially early in the disease's progression, but its effectiveness diminishes in later stages.
Article Synopsis
- Endovascular embolization is a minimally invasive method for treating blood vessel lesions, using liquid agents to block blood flow under X-ray guidance.
- Histoacryl, a common liquid embolic agent, has limitations like poor X-ray visibility and strong adhesion to the delivery device, prompting the research into alternative agents.
- The study developed and tested a new agent called 4-iodobutyl 2-cyanoacrylate (IBCA), which showed promising results in experiments with rabbits and swine, indicating its potential for clinical use.
hsa-miR-CHA2, a novel microRNA, exhibits anticancer effects by suppressing cyclin E1 in human non-small cell lung cancer cells.
Biochim Biophys Acta Mol Basis Dis
August 2024
Despite considerable therapeutic advancements, the global survival rate for lung cancer patients remains poor, posing challenges in developing an effective treatment strategy. In many cases, microRNAs (miRNAs) exhibit abnormal expression levels in cancers, including lung cancer. Dysregulated miRNAs often play a crucial role in the development and progression of cancer.
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- The study investigates the role of anti-CHI3L1 antibodies in preventing skin inflammation caused by chitinase-3-like 1 (CHI3L1) during atopic dermatitis development.
- Results showed that the antibodies reduced symptoms like epidermal thickening and inflammatory cytokine levels in both animal models and reconstructed human skin.
- The findings suggest that targeting CHI3L1 could be a promising therapy for atopic dermatitis, potentially more effective than existing treatments like IL-4 antibodies.
Background/aims: Despite advances in imaging and endoscopic technology, diagnostic modalities for small bowel tumors are simultaneously performed. We investigated the discrepancy rate between each modality and predictive factors of discrepancy in patients with definite small bowel tumors.
Methods: Data of patients with definite small bowel tumors who underwent both device-assisted enteroscopy (DAE) and computed tomography (CT) were retrieved from web-based enteroscopy registry database in Korea.
Enveloped viruses pose a significant threat to human health, as evidenced by the recent COVID-19 pandemic. Although current vaccine strategies have proven effective in preventing viral infections, the development of innovative vaccine technologies is crucial to fortify our defences against future pandemics. In this study, we introduce a novel platform called cell-engineered virus-mimetic nanovesicles (VNVs) and demonstrate their potential as a vaccine for targeting enveloped viruses.
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- * The study involved 59 patients who were randomly assigned to either ADT alone for at least 2 years or ADT plus pelvic radiation therapy, with a focus on comparing adverse events and quality of life between the two groups.
- * Results showed that while the combination therapy (ADT + RT) had higher rates of certain acute and late adverse events, it did not significantly worsen the overall quality of life compared to ADT alone, although the urinary and bowel domains experienced temporary decreases.
Purpose: The original eCura system was designed to stratify the risk of lymph node metastasis (LNM) after endoscopic resection (ER) in patients with early gastric cancer (EGC). We assessed the effectiveness of a modified eCura system for reflecting the characteristics of undifferentiated-type (UD)-EGC.
Materials And Methods: Six hundred thirty-four patients who underwent non-curative ER for UD-EGC and received either additional surgery (radical surgery group; n=270) or no further treatment (no additional treatment group; n=364) from 18 institutions between 2005 and 2015 were retrospectively included in this study.