Publications by authors named "Jensa M Joseph"
Oxidative stress has recently been identified as an important mediator of cardiovascular diseases. The need to find efficient antioxidant molecules is essential in the disease's prevention. Therefore, the present study aimed to evaluate the potential of microalgae bioactive in protecting H9c2 cardiomyoblasts from HO-induced oxidative stress.
View Article and Find Full Text PDFDiabetes mellitus (DM)-induced cardiac morbidities have been the leading cause of death among diabetic patients. Recently, sodium-glucose cotransporter-2 (SGLT-2) inhibitors including empagliflozin (EMPA), which have been approved for the treatment of DM, have gained attention for their cardioprotective effect. The mechanism by which SGLT-2 inhibitors exert their cardioprotective effect remains unclear.
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- Cisplatin is a common treatment for lung adenocarcinoma, but resistance and side effects are major issues; researchers are exploring drug combinations to improve outcomes.
- In this study, the combination of cisplatin with BI-D1870, an RSK inhibitor, was tested on A549 lung adenocarcinoma cells to see how it affected cell behavior like migration and apoptosis.
- Results showed that the drug combination enhanced the effectiveness of cisplatin by reducing cell migration, increasing activation of apoptotic pathways, and altering cell cycle dynamics, suggesting a potential new strategy to overcome cisplatin resistance.
Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and hearing loss. A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity.
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