A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum.

Corynebacterium glutamicum is the major host for the industrial production of amino acids and has become one of the best studied model organisms in microbial biotechnology. Rational strain construction has led to an improvement of producer strains and to a variety of novel producer strains with a broad substrate and product spectrum. A key factor for the success of these approaches is detailed knowledge of transcriptional regulation in C.

Melanocyte antigen triggers autoimmunity in human psoriasis.

Psoriasis vulgaris is a common T cell-mediated inflammatory skin disease with a suspected autoimmune pathogenesis. The human leukocyte antigen (HLA) class I allele, HLA-C*06:02, is the main psoriasis risk gene. Epidermal CD8(+) T cells are essential for psoriasis development.

Analysis of the paired TCR α- and β-chains of single human T cells.

Analysis of the paired i.e. matching TCR α- and β-chain rearrangements of single human T cells is required for a precise investigation of clonal diversity, tissue distribution and specificity of protective and pathologic T-cell mediated immune responses.

The TetR-type transcriptional regulator FasR of Corynebacterium glutamicum controls genes of lipid synthesis during growth on acetate.

The addition of fatty acids to either Escherichia coli or Bacillus subtilis elicits an elaborate cellular response of the lipid metabolism. We found that in Corynebacterium glutamicum the expression of accD1 encoding the β-subunit of the essential acetyl-CoA carboxylase is repressed in acetate-grown cells without the addition of fatty acids. The TetR-type transcriptional regulator NCgl2404, termed FasR, was identified and deleted.

The 3' ends of mature transcripts are generated by a processosome complex in fission yeast mitochondria.

In this article, we report on the genetic analysis of the Schizosaccharomyces pombe open reading frames SPCC1322.01 and SPAC637.11, respectively, which encode proteins that are similar to the exoribonuclease Dss1p and the RNA helicase Suv3p, respectively, forming the mitochondrial degradosome of Saccharomyces cerevisiae.

[Eagle syndrome: diagnostic imaging and therapy].

In the case of clinical symptoms such as dysphagia, foreign-body sensation and chronic neck or facial pain close to the ear, an Eagle syndrome should be considered in the differential diagnosis. Rational diagnostics and therapy are elucidated on the basis of four case reports. Four patients presented in the outpatients clinic with chronic complaints on chewing and a foreign-body sensation in the tonsil region.

[Differential diagnosis of tailgut cyst in the case of a rectal carcinoma with presacral mass].

Cystic masses of various different origins and degrees of malignancy occur in the presacral space. Apart from benign, malignant and acute inflammatory masses, the benign lesions include a group of cystic structures to which the dysgenetic cysts belong. The tailgut cyst is a relatively rare type of gastrointestinal origin from this group.

[Selective embolisation of posttraumatic intractable epistaxis].

Idiopathic or trauma-related nose-bleeds can in rare cases be an intractable clinical picture in which normal conservative measures fail. Further therapeutic options that can be applied are surgical vascular ligature or selective endovascular occlusion. We report on a patient who developed hemodynamically relevant epistaxis due to splanchnocranial injuries after falling from his bicycle.

[Diagnostic imaging and therapy of chondroblastoma].

The chondroblastoma is a rare lytic osseous lesion, which is typically to be found in the epiphyses of the long tubular bones. We present a case report with the differential diagnostic imaging and the surgical therapy of a chondroblastoma of the proximal tibial epiphysis. A 16-year-old male presented in the traumatological accident and emergency centre with knee pain of unclear origin that had been increasing for several months.