Publications by authors named "Jens M Schroeder"
Article Synopsis
- - The study identified a specific antifungal factor, redS100A7, produced in psoriasis lesions that inhibits various fungi, particularly Trichophyton rubrum and Aspergillus fumigatus, by affecting their zinc homeostasis.
- - RedS100A7's antifungal activity relies on its cysteine structure, as mutants lacking it lose this ability, and its mode of action involves inducing programmed cell death in certain fungi, supported by various cell analysis techniques.
- - The efficacy of redS100A7 and another Zn(2+)-chelator, TPEN, as antifungals was confirmed in animal models, indicating their potential as new therapeutic options for fungal infections.
Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent.
View Article and Find Full Text PDFAntimicrobial peptides such as defensins provide nonspecific mucosal defense against a multitude of microorganisms. Recently, it has been shown that luminal bacteria may invade the mucosa in inflammatory bowel diseases, suggesting a defect in innate mucosal immunity. The aim of this study was to investigate the expression of human beta-defensins (HBD) in controls, Crohn's disease (CD), ulcerative colitis (UC), and unspecific inflammation.
View Article and Find Full Text PDF