Publications by authors named "Jens Kosse"
Article Synopsis
- * In a study of 306 patients, pelvic LAE was performed in 35.6% of cases, with pelvic nodal involvement found in 18.5%, primarily in patients with more advanced nodal status (≥pN2a).
- * Adjuvant RT was given to 64.4% of the patients, but only half of those with pelvic nodal involvement received it, highlighting a significant risk of recurrence, particularly in cases with higher nodal status, while suggesting that
Pelvic Lymphadenectomy in Vulvar Cancer - Does it make sense?
Geburtshilfe Frauenheilkd
December 2020
Article Synopsis
- The 2015 updated German guidelines on pelvic lymphadenectomy (LAE) for vulvar cancer patients recommend surgical lymph node staging for those at higher risk, but defining this risk is still unclear.
- Two German patient populations have been analyzed to study the impact of lymph node metastasis, one including 1,618 patients and another 514 patients, with a small number undergoing pelvic LAE.
- Findings indicate that about 80% of patients who had pelvic LAE were also positive for inguinal lymph nodes, and pelvic lymph node staging may not be necessary for many node-positive patients, especially those with low-grade disease.
Objective: In vulvar cancer (VSCC), the course of disease with regard to localization of recurrence and relation of different recurrence sites is poorly described.
Methods: The AGO CaRE-1 study is a retrospective survey of treatment patterns and prognostic factors in vulvar cancer. Patients (pts) with primary VSCC, FIGO stage ≥1B treated in Germany from 1998 to 2008 were included in a centralized database (n = 1618).
Article Synopsis
- Lymph node metastasis is crucial for determining prognosis in vulvar cancer, and understanding risk factors can improve treatment strategies.
- A study analyzed 1162 patients undergoing radical groin dissection, identifying factors linked to the prevalence and extent of lymph node metastases.
- Key findings revealed that lymphovascular space invasion, tumor stage, and depth of infiltration significantly correlate with the likelihood of lymph node metastasis, with tumor stage also affecting the number of metastases.
Article Synopsis
- The AGO-CaRE-1 study compared the outcomes of two surgical approaches for vulvar cancer: isolated sentinel lymph node dissection (SLND) and radical lymph node dissection (LND), focusing on patient recurrence rates and survival outcomes.
- Data was retrospectively collected from 772 patients treated between 1998 and 2008 at 29 centers, specifically looking at those with FIGO stage ≥1B and tumors smaller than 4 cm.
- Results showed no significant differences in recurrence rates or progression-free survival between patients who underwent SLND and those who had LND, suggesting both methods are similarly effective for node-negative patients with smaller tumors.
Aim Of The Study: A tumour-free pathological resection margin of ≥8 mm is considered state-of-the-art. Available evidence is based on heterogeneous cohorts. This study was designed to clarify the relevance of the resection margin for loco-regional control in vulvar cancer.
View Article and Find Full Text PDFAdverse event management of oral mucositis in patients with breast cancer.
Breast Care (Basel)
April 2014
Article Synopsis
- Oral mucositis (OM) is a common and significant side effect of cancer treatments, varying in incidence and severity among patients and therapies.
- The progression of chemotherapy-induced OM can be broken down into five distinct phases, while OM from targeted therapies has different characteristics and impacts.
- OM severely affects the quality of life for patients, causing pain and nutritional issues, and although many potential treatments exist, there is currently no definitive solution for prevention or management.
Article Synopsis
- The study explored the role of the peroxynitrite-PARP pathway in inflammation and cell death following vascular gamma irradiation in a surgical model using male rats.
- After carotid surgery, some rats were irradiated with doses of 15 Gy or 20 Gy, while others served as controls to assess the effects of both injury and radiation.
- Results showed that, although irradiation significantly reduced neointima formation, it triggered considerable inflammation and activation of the peroxynitrite-PARP pathway, which could lead to negative effects like fibrosis in the blood vessels.
Article Synopsis
- The study explored how the peroxynitrite-PARP pathway affects neointima formation in a rat model after carotid endarterectomy, testing various treatments including irradiation and PARP inhibitors.
- Six groups of rats were treated differently to see how each affected neointima formation and vascular remodeling after the surgery.
- Results showed that combining PARP inhibition with higher dose irradiation effectively reduced neointima formation and the unwanted activation of the peroxynitrite-PARP pathway, suggesting a potential strategy to prevent restenosis after vascular surgery.
Poly(ADP-ribose) polymerase inhibition reverses vascular dysfunction after gamma-irradiation.
Int J Radiat Oncol Biol Phys
August 2006
Article Synopsis
- The study investigates how gamma-irradiation can cause DNA damage and subsequent endothelial dysfunction due to reactive oxygen species, particularly focusing on the role of the enzyme PARP.
- Researchers exposed aorta rings to gamma-irradiation and then assessed their vascular response, both with and without the PARP inhibitor INO-1001, over periods of 1 and 7 days.
- Results showed that while vasoconstriction was reduced after irradiation, vasorelaxation was actually enhanced, and treatment with INO-1001 successfully restored normal vascular function, suggesting its potential as a therapeutic option for radiation-induced vascular issues.
Article Synopsis
- - The study aimed to explore the role of the peroxynitrite-PARP pathway in the formation of neointima (a thickened layer of tissue) following carotid endarterectomy in rats, and how inhibiting PARP with a specific drug (INO-1001) affects vascular remodeling.
- - Male Sprague-Dawley rats were divided into three groups—sham-operated, control with endarterectomy, and endarterectomy with PARP inhibitor treatment—and analyzed for neointima formation and vascular changes after 21 days.
- - Results showed that the PARP inhibitor significantly reduced the area and thickness of neointima and the level of inflammation compared to the control group, suggesting potential therapeutic benefits in
Article Synopsis
- - The study aimed to test a new treatment for preventing restenosis (narrowing of arteries) after endarterectomy in a rat model using gamma-irradiation post-surgery.
- - Rats were divided into groups receiving different doses of radiation (15 Gy and 20 Gy) after the surgery, and results showed a significant decrease in neointima formation compared to controls.
- - The findings suggest that gamma-irradiation can effectively reduce neointimal hyperplasia while still allowing for some re-endothelialization, indicating a potential new strategy to improve long-term outcomes after endarterectomy procedures.