Publications by authors named "Jens Glienke"
Background: The Hedgehog (Hh) signaling pathway regulates a variety of developmental processes, including vasculogenesis, and can also induce the expression of pro-angiogenic factors in fibroblasts postnatally. Misregulation of the Hh pathway has been implicated in a variety of different types of cancer, including pancreatic and small-cell lung cancer. Recently a putative antagonist of the pathway, Hedgehog-interacting protein (HIP), was identified as a Hh binding protein that is also a target of Hh signaling.
View Article and Find Full Text PDFEphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration.
Biochem Biophys Res Commun
January 2004
Signaling between the ligand ephrinB2 and the respective receptors of the EphB class is known to play a vital role during vascular morphogenesis and angiogenesis. The relative contribution of each EphB receptor type present on endothelial cells to these processes remains to be determined. It has been shown that ephrinB2-EphB receptor signal transduction leads to a repulsive migratory behavior of endothelial cells.
View Article and Find Full Text PDFArticle Synopsis
- Researchers discovered that the gene CRIM1 is significantly upregulated in endothelial cells during the formation of capillary-like structures, alongside other previously undescribed genes.
- Utilizing antisense technology to inhibit CRIM1 expression revealed that its absence disrupts capillary-like structure formation in these cells.
- CRIM1 is a glycosylated type I transmembrane protein found at cell-to-cell contact points and is expressed in the inner lining of blood vessels, suggesting its potential role in angiogenesis and capillary maintenance.