Neuroimmunological and neuroenergetic aspects in exercise-induced fatigue.

Feelings of fatigue not only occur in chronic and acute disease states, but also during prolonged strenuous exercise as a symptom of exhaustion. The underlying mechanisms of fatigue in diseases seem to rely on neuroinflammatory pathways. These pathways are interesting to understand exerciseinduced fatigue regarding immune system to brain signaling and effects of cerebral cytokines.

The inflammation paradox: Why are Tsimane protected against Western diseases while Westerners are not?

We here describe two apparent paradoxes concerning high CRP levels and NCD risk. One has emerged from observational studies in the Amazon region showing that the indigenous Tsimane in Bolivia appear protected against non-communicable diseases (NCDs) such as obesity, type 2 diabetes, and cardiovascular diseases despite increased inflammatory markers. These findings stand in contrast to Western societies, where an increasing body of evidence demonstrates that low-grade-inflammation is the driver of NCDs.

The sedentary (r)evolution: Have we lost our metabolic flexibility?

During the course of evolution, up until the agricultural revolution, environmental fluctuations forced the human species to develop a flexible metabolism in order to adapt its energy needs to various climate, seasonal and vegetation conditions. Metabolic flexibility safeguarded human survival independent of food availability. In modern times, humans switched their primal lifestyle towards a constant availability of energy-dense, yet often nutrient-deficient, foods, persistent psycho-emotional stressors and a lack of exercise.

Corrigendum to "Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The "Study of Origin"".

[This corrects the article DOI: 10.1155/2016/6935123.].

Prototype for in situ detection of atmospheric NO3 and N2O5 via laser-induced fluorescence.

We describe a prototype designed for in situ detection of the nitrate radical (NO3) by laser-induced fluorescence (LIF) and of N2O5 by thermal dissociation followed by LIF detection of NO3. An inexpensive 36 mW continuous wave multi-mode diode laser at 662 nm is used to excite NO3 in the B2E'(0000) <-- X2A'2(0000) band. Fluorescence is collected from 700 to 750 nm.