Publications by authors named "Jens Ade"
Characterizing the interactions that SARS-CoV-2 viral RNAs make with host cell proteins during infection can improve our understanding of viral RNA functions and the host innate immune response. Using RNA antisense purification and mass spectrometry, we identified up to 104 human proteins that directly and specifically bind to SARS-CoV-2 RNAs in infected human cells. We integrated the SARS-CoV-2 RNA interactome with changes in proteome abundance induced by viral infection and linked interactome proteins to cellular pathways relevant to SARS-CoV-2 infections.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on the presynaptic active zone (PAZ) in the brain, which is crucial for neurotransmitter release and influenced by specific proteins.
- Researchers developed a new method to isolate PAZ complexes from different brain regions (olfactory bulb, hippocampus, cerebellum) to analyze their protein compositions.
- The findings revealed significant differences in the amounts of certain proteins involved in calcium regulation and neural functions, suggesting that while the basic structure of PAZ is similar across regions, its protein makeup varies to meet specific brain needs.