Publications by authors named "Jennyfer Martins de Carvalho"
Paricalcitol prevents renal tubular injury induced by ischemia-reperfusion: Role of oxidative stress, inflammation and ATR.
Mol Cell Endocrinol
December 2024
The vitamin D receptor (VDR) is associated with antioxidative and anti-inflammatory effects and modulation of the renin-angiotensin-aldosterone system. This study evaluated whether VDR agonist paricalcitol protects renal ischemia-reperfusion (IR) induced tubular injury in rats by evaluating: 1) ATP-dependent tubular Na transport; 2) renal redox signaling; 3) renal content of proinflammatory cytokines TNF-α and IL-6; and 4) renal content of renin and angiotensin II receptor type 1 (ATR). Paricalcitol prevented IR-induced tubular injury, evidenced by the prevention of histopathological changes and renal fibrosis with preservation of the activity of ATP-dependent Na transporters in the renal cortex.
View Article and Find Full Text PDFEffect of neonatal melatonin administration on behavioral and brain electrophysiological and redox imbalance in rats.
Front Neurosci
October 2023
Article Synopsis
- The study investigates the effects of melatonin (MLT) on anxiety and memory in developing rats, analyzing different doses (10 mg/kg and 40 mg/kg) administered early in life.
- MLT-10 showed a reduction in anxiety and improved memory tasks, whereas MLT-40 did not have these positive effects.
- Additionally, varying doses of MLT influenced the speed of cortical spreading depression (CSD), with MLT-10 slowing down CSD propagation, while MLT-40 accelerated it, indicating dose-dependent effects on brain excitability.
Aims: The yeast Dekkera bruxellensis is a Crabtree-positive yeast that tends towards the oxidative/respiratory metabolism in aerobiosis. However, it is more sensitive to H2O2 than Saccharomyces cerevisiae. In order to investigate this metabolic paradox, the present work aimed to uncover the biological defence mechanism used by this yeast to tolerate the presence of exogenous H2O2.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to review literature on how COVID-19 affects pregnant women, focusing on placental changes and potential vertical transmission of the virus.
- A systematic search was conducted across several scientific databases using specific keywords related to pregnancy and COVID-19.
- Findings show some evidence of the virus in the amniotic fluid and umbilical cord, but overall, there is limited evidence of direct viral transmission to the placenta and associated morphological changes.