Publications by authors named "Jennyfer Castro"
Article Synopsis
- Research into the antitumor effects of gold compounds is gaining traction, with a focus on their complex action mechanisms.
- The primary mechanism studied is the inhibition of thioredoxin reductase by auranofin, which disrupts the redox balance in cells and induces oxidative stress leading to cell death.
- The review compiles data from the last ten years on how different gold compound structures affect reactive oxygen species (ROS) production and enzyme activity, revealing varied efficacy and potential alternative mechanisms beyond thioredoxin reductase inhibition.
Gold(I) N-heterocyclic carbenes have been explored for their therapeutic potential against several diseases. Neglected tropical diseases, including leishmaniasis, Chagas disease, and viral infections, such as zika, mayaro, and chikungunya, urgently require new treatment options. The emergent SARS-CoV-2 also demands significant attention.
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