Publications by authors named "Jenny Zu"
Insulin-mechanistic target of rapamycin (mTOR) signaling drives anabolic growth during organismal development; its late-life dysregulation contributes to aging and limits lifespans. Age-related regulatory mechanisms and functional consequences of insulin-mTOR remain incompletely understood. Here, we identify LPD-3 as a megaprotein that orchestrates the tempo of insulin-mTOR signaling during C.
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- Insulin-mTOR signaling plays a crucial role in growth during development, but its dysregulation can negatively affect aging and lifespan.
- Researchers identified LPD-3 as a megaprotein that helps regulate this signaling during aging, with the insulin agonist INS-7 being linked to shortened lifespans in specific mutants.
- LPD-3 appears to reduce aging effects by interacting with key components of mTOR signaling and influencing lipid metabolism, suggesting that its decline over time contributes to lifespan limitations.