Publications by authors named "Jenny Yanyan Long"
Article Synopsis
- Talin is a key protein that connects integrin receptors to the actin cytoskeleton, crucial for muscle attachment and stability.
- Phosphorylation of Talin, particularly at the T152 site during muscle development, affects its localization and functionality, with a mutated version showing reduced effectiveness.
- The kinase Slik is responsible for phosphorylating Talin at T152, and its absence leads to similar issues seen with the Talin mutation, highlighting its importance in muscle attachment.
Zasp52 is a member of the PDZ-LIM domain protein family in Drosophila, which comprises Enigma, ENH, ZASP, Alp, CLP36, RIL, and Mystique in vertebrates. Drosophila Zasp52 colocalizes with integrins at myotendinous junctions and with α-actinin at Z-disks, and is required for muscle attachment as well as Z-disk assembly and maintenance. Here we document 13 Zasp52 splice variants giving rise to six different LIM domains.
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