Publications by authors named "Jenny Yang"

Consumer-grade mobile devices are used by billions worldwide. Their ubiquity provides opportunities to robustly capture everyday cognition. 'Intuition' was a remote observational study that enrolled 23,004 US adults, collecting 24 months of longitudinal multimodal data via their iPhones and Apple Watches using a custom research application that captured routine device use, self-reported health information and cognitive assessments.

View Article and Find Full Text PDF

In electrochemical analysis, mechanism assignment is fundamental to understanding the chemistry of a system. The detection and classification of electrochemical mechanisms in cyclic voltammetry set the foundation for subsequent quantitative evaluation and practical application, but are often based on relatively subjective visual analyses. Deep-learning (DL) techniques provide an alternative, automated means that can support experimentalists in mechanism assignment.

View Article and Find Full Text PDF

Background: Rheumatic heart disease (RHD) remains as 1 of the major contributors to indirect pregnancy-related mortality and morbidity worldwide and disproportionately affects marginalized populations.

Objectives: In this scoping review, the authors sought to explore the socioeconomic, cultural, and health care access-related causes of global disparities in outcomes of pregnancy among individuals with RHD.

Methods: We performed a literature search of all studies published between January 1, 1990, and January 1, 2022, that investigated causes for disparate outcomes in pregnant individuals with RHD.

View Article and Find Full Text PDF

Substantial loss of cardiomyocytes during heart attacks and onset of other cardiovascular diseases is a major cause of mortality. Preservation of cardiomyocytes during cardiac injury would be the most effective strategy to manage these diseases in clinic. However, there is no effective treatment strategy that is able to prevent cardiomyocyte loss.

View Article and Find Full Text PDF
Article Synopsis
  • Fuel-forming reactions like the hydrogen evolution reaction (HER) and CO reduction (COR) are essential for a carbon-neutral economy, with metal hydride intermediates playing a crucial role in these processes.
  • The research focuses on controlling hydride reactivity to create selective electrocatalysts operating at low energy costs, examining the free energy changes during catalytic steps and synthesizing intermediates to better understand the process.
  • Strategies explored include optimizing hydricity to enhance CO reduction to formate while minimizing unwanted side reactions, as well as designing catalysts that reduce HER rates using electrostatic and steric effects.
View Article and Find Full Text PDF

Salen ligands (salen = ,'-ethylenebis(salicylimine)) are well-known for their versatility and widespread utility in chelating metal complexes. However, installation of hydrogen-bonding units on the salen framework, particularly functional groups that require amine-based precursors such as (thio)ureas, is difficult to achieve without the use of protecting group strategies. In this report, we show that the phenylketone analog of salicyladehyde is a stable alternative that enables the facile installation of hydrogen bonding (thio)urea groups on the salen scaffold, thus imparting anion binding abilities to a metal salen complex.

View Article and Find Full Text PDF

Heart rate variability (HRV) is an important metric in cardiovascular health monitoring. Spectral analysis of HRV provides essential insights into the functioning of the cardiac autonomic nervous system. However, data artefacts could degrade signal quality, potentially leading to unreliable assessments of cardiac activities.

View Article and Find Full Text PDF

Background: Preterm birth (PTB) is associated with significant neonatal mortality and morbidity. Universal measurement of cervical length has been proposed as a screening tool to direct intervention to prevent PTB.

Aim: To assess the impact of the introduction of sonographic mid-trimester cervical length screening on the use of cervical cerclage and PTB.

View Article and Find Full Text PDF

During cortical spreading depolarization (CSD), neurons exhibit a dramatic increase in cytosolic calcium, which may be integral to CSD-mediated seizure termination. This calcium increase greatly exceeds that during seizures, suggesting the calcium source may not be solely extracellular. Thus, we sought to determine if the endoplasmic reticulum (ER), the largest intracellular calcium store, is involved.

View Article and Find Full Text PDF

Right ventricle (RV)-to-pulmonary artery (PA) coupling measured by the ratio of echocardiography-derived tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery systolic pressure (PASP) is a meaningful prognostic marker in pulmonary hypertension (PH). It's unclear if balloon pulmonary angioplasty (BPA) treatment of chronic thromboembolic pulmonary hypertension (CTEPH) alters RV-PA coupling measured by TAPSE/PASP. We reviewed CTEPH patients treated with BPA at our institution who had a transthoracic echocardiogram (TTE) before BPA and a follow-up TTE at any point during BPA.

View Article and Find Full Text PDF

Bipyridines and azaarenes are an important class of ligands that impart unique and tunable properties to transition metal complexes and catalysts. While some derivatives are commercially available, noncommercial analogues are often challenging to prepare and purify. Herein, we report a general nucleophilic aromatic substitution reaction that converts cationic trimethylaminated bipyridines into a series of functionalized bipyridines.

View Article and Find Full Text PDF
Article Synopsis
  • * LMICs face challenges like limited funding, outdated tech, and lack of expertise, making it difficult to apply AI models developed in HICs without adaptation.
  • * The study assesses the use of UK-developed AI models in Vietnam, highlighting the need for personalized approaches to improve performance and address local healthcare challenges effectively.
View Article and Find Full Text PDF

Escalating levels of carbon dioxide (CO) in the atmosphere have motivated interest in CO capture and concentration from dilute streams. A guanidino-functionalized aromatic 1,4-bis(tetramethylguanidino)benzene (1,4-btmgb) was evaluated both as a redox-active sorbent and as a pH swing mediator for electrochemical CO capture and concentration. Spectroscopic and crystallographic studies demonstrate that 1,4-btmgb reacts with CO in water to form 1,4-btmgbH(HCO ).

View Article and Find Full Text PDF

Calcium-sensing receptor (CaSR), a family C G-protein-coupled receptor, plays a crucial role in regulating calcium homeostasis by sensing small concentration changes of extracellular Ca, Mg, amino acids (e.g., L-Trp and L-Phe), small peptides, anions (e.

View Article and Find Full Text PDF
Article Synopsis
  • ProAgio is a targeted protein that induces apoptosis in cancer-associated fibroblasts (CAFs) and angiogenic endothelial cells (aECs) by binding to integrin αβ.
  • Its application leads to significant changes in tumor immunity, decreasing regulatory T-cells (CD Treg) and myeloid-derived suppressor cells (MDSCs), while increasing CD T-cells and the ratio of M1 to M2 macrophages.
  • By depleting fibrotic stroma, ProAgio enhances the delivery of anti-PDL-1 antibodies, resulting in improved effectiveness of checkpoint inhibitors in treating lung cancer.
View Article and Find Full Text PDF

Nonalcoholic steatohepatitis (NASH) and alcoholic hepatitis (AH) affect a large part of the general population worldwide. Dysregulation of lipid metabolism and alcohol toxicity drive disease progression by the activation of hepatic stellate cells and the capillarization of liver sinusoidal endothelial cells. Collagen deposition, along with sinusoidal remodeling, alters sinusoid structure, resulting in hepatic inflammation, portal hypertension, liver failure, and other complications.

View Article and Find Full Text PDF

Introduction: Chronic obstructive pulmonary disease (COPD) is currently listed as the 3 leading cause of death in the United States. Accumulating data shows the association between COPD occurrence and the usage of electronic nicotine delivery systems (ENDS) in patients. However, the underlying pathogenesis mechanisms of COPD have not been fully understood.

View Article and Find Full Text PDF

The analysis of extensive electronic health records (EHR) datasets often calls for automated solutions, with machine learning (ML) techniques, including deep learning (DL), taking a lead role. One common task involves categorizing EHR data into predefined groups. However, the vulnerability of EHRs to noise and errors stemming from data collection processes, as well as potential human labeling errors, poses a significant risk.

View Article and Find Full Text PDF
Article Synopsis
  • * The development of electrified processes utilizing captured CO aims to eliminate traditional methods of gas compression and storage, addressing both environmental and economic concerns.
  • * This review examines the tuning of ILs and DESs for reactive capture and conversion, focusing on their mechanisms for CO chemisorption and electroreduction, as well as their bulk and interfacial properties related to the process.
View Article and Find Full Text PDF

Objective: Previous work identified an association between genetics and neurodevelopmental delays in patients with nonsyndromic craniosynostosis. The authors investigated the role of genetic mutations on behavioral outcomes of patients with treated sagittal synostosis.

Methods: Parents of children aged 6-18 years with surgically corrected sagittal synostosis were recruited to complete the Child Behavioral Checklist (overall behavioral problems), Conners 3rd Edition-Parent (attention-deficit/hyperactivity disorder), Social Responsiveness Scale 2nd Edition (autism spectrum disorder [ASD]), and Behavior Rating Inventory of Executive Function 2nd Edition (executive function).

View Article and Find Full Text PDF
Article Synopsis
  • Collaborative AI partnerships between high-income countries (HICs) and low- to middle-income countries (LMICs) are becoming more frequent, mainly due to resource challenges in LMICs.
  • Ensuring fairness and equity in these collaborations is critical, as differences between HIC and LMIC hospitals can impact performance outcomes.
  • The study, through a COVID-19 screening case study, shows that using bias mitigation methods in algorithms can enhance outcome fairness and maintain diagnostic accuracy across both settings.
View Article and Find Full Text PDF

Despite an abundance of support for culturally inclusive learning environments, there is little consensus regarding how to change educational contexts to effectively and sustainably foster cultural inclusion. To address this gap, we report findings from a research-practice partnership that leveraged the Culture Cycle Framework (CCF) to expand educators' praxis to include both independent and interdependent models of self. Most U.

View Article and Find Full Text PDF

Background: Capsular contracture (CC) is a leading cause of morbidity in implant-based breast surgery. Implant surface texture has been implicated in CC development, yet its etiopathogenesis remains unclear. We conducted a systematic review to determine the influence of implant surface texture on cellular and molecular mechanisms involved in the etiopathogenesis of CC.

View Article and Find Full Text PDF
Article Synopsis
  • The rapid increase in memory and computing power is leading to more complex and imbalanced datasets, particularly in clinical data where minority events are rare compared to the majority class.
  • The authors propose a new framework for imbalanced classification using reinforcement learning, which utilizes dueling and double deep Q-learning methods and is tailored for multi-class scenarios.
  • Their approach demonstrates superior performance over existing methods in real-world clinical case studies, promoting fairer classification and better predictions for minority classes.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionnll926rulf3rjq0unltmnuiku4f3kdj2): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once