Modafinil augmentation for residual symptoms of fatigue in patients with a partial response to antidepressants.

Objective: To evaluate the literature discussing the use of modafinil in the treatment of residual symptoms of fatigue in patients with depression.

Data Sources: PubMed (1966-March 2007) and International Pharmaceutical Abstracts (1970-March 2007) were searched using the key words modafinil and depression. A manual search of the reference section of the articles retrieved was conducted to identify articles not indexed in either of these sources.