Development and characteristics of the Provincial Overdose Cohort in British Columbia, Canada.

Introduction: British Columbia (BC), Canada declared a public health emergency in April 2016 for opioid overdose. Comprehensive data was needed to identify risk factors, inform interventions, and evaluate response actions. We describe the development of an overdose cohort, including linkage strategy, case definitions, and data governance model, and present the resulting characteristics, including data linkage yields and case overlap among data sources.

At-a-glance - Impact of drug overdose-related deaths on life expectancy at birth in British Columbia.

We quantified the contributions of leading causes of death and drug overdose to changes in life expectancy at birth over time and inequalities by sex and socioeconomic status in British Columbia. From 2014 to 2016, life expectancy at birth declined by 0.38 years and drug overdose deaths (mainly opioid-involved) contributed a loss of 0.

Incidence and prevalence trends of youth-onset type 2 diabetes in a cohort of Canadian youth: 2002-2013.

Objective: Youth-onset type 2 diabetes is an emerging disease. We estimated incidence and prevalence trends of youth-onset type 2 diabetes between 2002 and 2013 in the Canadian province of British Columbia.

Methods: This population-based cohort study used a validated diabetes case-finding definition and algorithm to differentiate type 2 from type 1 diabetes to identify youth <20 years with type 2 diabetes within linked population-based administrative data.

Type 1 diabetes incidence and prevalence trends in a cohort of Canadian children and youth.

Background And Objective: Incidence rates of type 1 diabetes have long been on the rise across the globe, however, there is emerging evidence that the rate of rise may be slowing. The objective of this study was to describe trends in the incidence and prevalence of type 1 diabetes in a sample of Canadian children and youth.

Methods: Cases were extracted using linked administrative datasets and a validated diabetes case-finding definition.

Impact of rosiglitazone meta-analysis on use of glucose-lowering medications.

Background: In May 2007 Nissen and Wolski reported the results of a meta-analysis showing an association between use of rosiglitazone and increased risk of myocardial infarction (N Engl J Med 2007;356(24):2457-2471). Rosiglitazone is an insulin-sensitizing agent used to control blood glucose levels in patients with type 2 diabetes. Subsequent analyses provided evidence that the meta-analysis led to a decline in new and prevalent use of rosiglitazone.

Statin adherence and risk of accidents: a cautionary tale.

Background: Bias in studies of preventive medications can occur when healthier patients are more likely to initiate and adhere to therapy than less healthy patients. We sought evidence of this bias by examining associations between statin exposure and various outcomes that should not be causally affected by statin exposure, such as workplace and motor vehicle accidents.

Methods And Results: We conducted a prospective cohort study of statin patients using data from British Columbia, Canada, a multiethnic society with a population of 4.