In utero exposure to gestational diabetes mellitus (GDM) is associated with adverse long-term outcomes. Little is known about how mothers perceive these outcomes and the support they need for optimal outcomes for their children. We aimed to explore how women perceive the risk of adverse outcomes for their children exposed to GDM and the support they require for their optimal health.
View Article and Find Full Text PDFImportance: Neonatal hypoglycemia is an important preventable cause of neurodevelopmental impairment, but there is a paucity of evidence to guide treatment.
Objective: To evaluate whether early, low-dose oral diazoxide for severe or recurrent neonatal hypoglycemia reduces time to resolution of hypoglycemia.
Design, Setting, And Participants: This 2-arm, placebo-controlled randomized clinical trial was conducted from May 2020 to February 2023 in tertiary neonatal units at 2 New Zealand hospitals.
Objective: To determine the relationship between transient neonatal hypoglycemia in at-risk infants and neurocognitive function at 6-7 years of corrected age.
Study Design: The pre-hPOD Study involved children born with at least 1 risk factor for neonatal hypoglycemia. Hypoglycemia was defined as ≥1 consecutive blood glucose concentrations <47 mg/dl (2.
Arch Dis Child Fetal Neonatal Ed
October 2024
Objective: To describe strategies used to maximise follow-up after a neonatal randomised trial, how these differed for families of different ethnicity, socioeconomic status and urban versus rural residence and investigate relationships between the difficulty of follow-up and rate of neurosensory impairment.
Method: hPOD was a multicentre randomised trial assessing oral dextrose gel prophylaxis for neonatal hypoglycaemia. Follow-up at 2 years was conducted from 2017 to 2021.
Objective: To investigate the effect of different doses of prophylactic dextrose gel on neurocognitive function and health at 6-7 years.
Design: Early school-age follow-up of the pre-hPOD (hypoglycaemia Prevention with Oral Dextrose) study.
Setting: Schools and communities.
Background: Routinely assessed outcomes in paediatric health studies may not reflect families' priorities. Increasing our understanding of childhood experiences of research participation may contribute to improving the quality of consent and better align study aims with the concerns of relevant communities.
Objective: To explore young adults' views on their participation in medical research during their childhood, specifically around the acceptability of consent and their priorities regarding health, development and well-being as potential trial outcomes.
Nutrient offsetting allows nutrient point source polluters to pay for diffuse source nutrient reductions, or improvements in nutrient load reductions from alternative point sources. These programs have the potential to provide a more cost-effective approach to achieve water quality goals in waterways compared to infrastructure upgrades. However, worldwide adoption of nutrient offset/trading has not been realized.
View Article and Find Full Text PDFImportance: Neonatal hypoglycemia is common, but its association with later neurodevelopment is uncertain.
Objective: To examine associations between neonatal hypoglycemia and neurocognitive outcomes at corrected age 2 years.
Design, Setting, And Participants: Exploratory cohort analysis of the Hypoglycaemia Prevention With Oral Dextrose (hPOD) randomized clinical trial was conducted.
Introduction: Infants with severe or recurrent transitional hypoglycaemia continue to have high rates of adverse neurological outcomes and new treatment approaches are needed that target the underlying pathophysiology. Diazoxide is one such treatment that acts on the pancreatic β-cell in a dose-dependent manner to decrease insulin secretion.
Methods And Analysis: Phase IIB, double-blind, two-arm, parallel, randomised trial of diazoxide versus placebo in neonates ≥35 weeks' gestation for treatment of severe (blood glucose concentration (BGC)<1.
Introduction: Routinely collected data can be linked to research data to create a rich dataset and inform practice. However, consent is normally required to link identifiable data. Reported rates of consent to data linkage for children ranged from 21% to 96%, but no studies have investigated different approaches to seeking consent for data linkage for school-age children.
View Article and Find Full Text PDFImportance: Prophylactic oral dextrose gel reduces neonatal hypoglycemia, but later benefits or harms remain unclear.
Objective: To assess the effects on later development of prophylactic dextrose gel for infants born at risk of neonatal hypoglycemia.
Design, Setting, And Participants: Prospective follow-up of a multicenter randomized clinical trial conducted in 18 Australian and New Zealand hospitals from January 2015 to May 2019.
Objectives: The aim of this study was to conduct New Zealand-specific research to inform the design of a pulse oximetry screening strategy that ensures equity of access for the New Zealand maternity population. Equity is an important consideration as the test has the potential to benefit some populations and socioeconomic groups more than others.
Setting: New Zealand has an ethnically diverse population and a midwifery-led maternity service.
Int J Group Psychother
October 2013
Research shows that elderly patients are fully capable of benefiting from psychotherapy, and often prefer this non-pharmacological treatment option. Further, there is consensus among geriatric clinicians and researchers that a group format for psychotherapy is likely especially helpful for the elderly. In this paper, we describe a unique group therapy program for elderly patients referred to a community outpatient setting for depression and/or anxiety.
View Article and Find Full Text PDFPsychopathic behaviour traits may be more common than many of us would think: 1 per cent of the population could be psychopaths. Psychopaths exploit any laxity in the recruitment process and can rise through the ranks as they are expert at deflecting criticism. An overriding characteristic is inability to work in team.
View Article and Find Full Text PDFBackground: audiological function is impaired in people with dementia and poor hearing is known to exaggerate the effects of cognitive deficits.
Objective: the objective of this study was to assess the effects of increasing auditory acuity by providing hearing aids to subjects with dementia who have mild hearing loss.
Method: subjects were screened for hearing impairment and fitted with a hearing aid according to standard clinical practice.
The purpose of this study was to compare the effect of structured training on recognition and appraisal of the timbre (tone quality) of musical instruments by postlingually deafened cochlear implant recipients. Twenty-four implant users (Nucleus CI24M) were randomly assigned to a control or a training group. The control group experienced only incidental exposure to music in their usual daily routine.
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