The impact of a cation channel blocker (furosemide) on Pseudomonas aeruginosa PAO1 biofilm architecture.

Objective: To determine if furosemide could have a role in inhibition of biofilm formation.

Study Design: A prospective study of 72-hour biofilms grown in the Calgary Biofilm Device (CBD) treated with furosemide and controls.

Methods: Bacteria were treated with furosemide and controls to determine its antiplanktonic properties.

Results of Caldwell-Luc after failed endoscopic middle meatus antrostomy in patients with chronic sinusitis.

Objectives/hypothesis: The Caldwell-Luc operation for treatment of medically refractory chronic maxillary sinusitis has largely been replaced by functional endoscopic sinus surgery. Despite this change, the Caldwell-Luc procedure still has well documented indications including treatment of both failed endoscopic middle meatus antrostomy and irreversible mucosal changes. The purpose of the study was to review the authors' experience and results of Caldwell-Luc procedure after failed endoscopic middle meatus antrostomy in patients clinically deemed to have irreversible mucosal changes.