Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats.

The present study examined the effects of paradoxical sleep (PS) deprivation on the oxidative stress parameters: lipid peroxidation, superoxide dismutase, glutathione peroxidase, and glutathione in brain regions: cerebral cortex, striatum, hippocampus, thalamus, hypothalamus, and brain stem of adult (8 months) and old (24 months) rats. PS deprivation (96 h) was performed by the classical flower pot technique. PS deprivation did not affect oxidative stress parameters in the striatum of both age groups; and the activity of glutathione peroxidase was not affected in any of the studied brain regions in both age groups.