The relationship of high-intensity cross-training with arterial stiffness.

Background: Central arterial stiffness is a cardiovascular risk factor that can be readily affected through engagement in physical exercise training, with resistance and aerobic exercise having disparate affects. Despite the growing popularity of high-intensity cross-training (HICT), little is currently known about the effects of this mixed modality exercise stimulus on arterial stiffness. Therefore, the purpose of this study was to characterize the arterial stiffness of habitual HICT participants aerobically active and sedentary controls using a cross-sectional design.

Effect of estrogen on calcium-handling proteins, beta-adrenergic receptors, and function in rat heart.

Regulation of cellular Ca(2+) cycling is central to myocardial contractile function. Loss of Ca(2+) regulation is associated with cardiac dysfunction and pathology. Estrogen has been shown to modify contractile function and to confer cardioprotection.

Sex differences in expression of calcium-handling proteins and beta-adrenergic receptors in rat heart ventricle.

Human studies reveal sex differences in myocardial function as well as in the incidence and manifestation of heart disease. Myocellular Ca(2+) cycling regulates normal contractile function; whereas cardiac dysfunction in heart failure has been associated with alterations in Ca(2+)-handling proteins. Beta-adrenergic receptor (beta-AR) signaling regulates activity of several Ca(2+)-handling proteins and alterations in beta-AR signaling are associated with heart disease.

Catheter-associated UTIs in patients after major gynaecological surgery.

A group of nurses undertook an audit across two hospitals comparing the incidence of catheter-related urinary tract infections in patients who had catheters inserted during major gynaecological surgery. The data suggests that using an anaesthetic lubricating gel for catheterisation reduces urinary tract infection rates for these patients.

Sex differences in the response of rat heart ventricle to calcium.

Calcium (Ca2+) is a key mediator of myocardial function. Calcium regulates contraction, and disruption of myocellular Ca2+ handling plays a role in cardiac pathologies such as arrhythmias and heart failure. This investigation examines sex differences in sensitivity of the contractile proteins to Ca2+ and myofibrillar Ca2+ delivery in the ventricular myocardium.