Publications by authors named "Jennifer Stefan"
Article Synopsis
- SARS-CoV-2, the virus responsible for COVID-19, produces various subgenomic RNAs (sgRNAs) that play roles in viral gene expression, though their functions are not entirely understood.
- Host agents like insulin and interferon-gamma, along with the virus's spike protein, enhance the expression of these sgRNAs by promoting the binding of a specific host protein complex to the viral RNA's 3'-end.
- A newly identified RNA element (SPEAR) in the virus's 3'-end increases sgRNA activity and viral translation, presenting a potential therapeutic target to reduce SARS-CoV-2 levels effectively.
